Letter | Published:

In vitro Transfer of Cell-mediated Immunity to Hepatitis B Antigen with RNA

Naturevolume 247pages377378 (1974) | Download Citation



THE immunological basis of the chronic carrier state for hepatitis B antigen (HBAg) in man remains ill-defined. Knowledge of experimental immunity to HBAg in animal models may provide an insight into the concepts and means of terminating the human chronic carrier state, which seems to be a reservoir for transmission of type B viral hepatitis. The in vitro and in vivo measurements of cell-mediated immunity to HBAg in guinea pigs have been previously reported1,3. The migration inhibition of peritoneal macrophages in the presence of HBAg is an excellent correlate of delayed hypersensitivity to HBAg in guinea pigs2. We now report the in vitro transfer of cell-mediated immunity to non-immune cells as measured by inhibition of migration in the presence of HBAg, using RNA extracted from the lymphoid tissue of guinea pigs immunised with HBAg.

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  1. Department of Clinical Pathology and Laboratory Medicine, University of California, San Francisco, California, 94143

    • , ALI B. IBRAHIM
    • , KASTURI R. RAO


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