Letter | Published:

Behavioural Effects of in utero Administration of Morphine

Naturevolume 247pages376377 (1974) | Download Citation



ALTHOUGH numerous studies have been concerned with the behavioural effects of opiates, relatively little attention has been paid to the offspring of females receiving an opiate during pregnancy. The matured offspring's response to stress and to the same drug are important issues in terms of current drug abuse and potential widespread application of opiate maintenance programmes. Since morphine is readily transferred across both placental and lacteal barriers1,2, we have studied the analgesic response to morphine in the offspring of mice receiving the drug during gestation and lactation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Shute, E., and Davis, E., Surg. Gynec. Obst., 57, 727 (1933).

  2. 2

    Blane, G. F., and Dobbs, H. E., Br. J. Pharmac., 30, 167 (1967).

  3. 3

    Glick, S. D., Greenstein, S., and Goldfarb, J., Behav. Biol. (in the press).

  4. 4

    Davis, J. D., and Miller, N. E., Science, N.Y., 141, 1286 (1963).

  5. 5

    Cochin, J., and Kornetsky, C., J. pharm. exp. Ther., 145, 1 (1964).

  6. 6

    Johannesson, T., and Milthers, K., Acta pharmacol Toxicol., 19, 241 (1962).

  7. 7

    Wikler, A., and Pescor, F. T., Psychopharmacologia, 10, 255 (1967).

Download references

Author information


  1. Department of Pharmacology, Mount Sinai School of Medicine, Fifth Avenue and 100th Street, New York, New York, 10029

    • , A. D. CHARAP
    •  & S. D. GLICK
  2. H. M. Singer Laboratory of Neurosciences and Addictive Diseases, Beth Israel Medical Center, 307 Second Avenue, New York, New York, 10003

    • , A. D. CHARAP
    •  & S. D. GLICK


  1. Search for B. ZIMMERBERG in:

  2. Search for A. D. CHARAP in:

  3. Search for S. D. GLICK in:

About this article

Publication history



Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.