Abstract
WE have reported the phenomenon of “minimal medium recovery” of heated Salmonella typhimurium LT2 (ref. 1) and how this phenomenon could be explained in terms of DNA damage caused by sequential exposure to heat and nutritionally complex medium2. We now show that treatment of S. typhimurium with rifampin also results in decreased viability on rich relative to minimal medium and that the DNA from these rifampin-treated bacteria exhibits breaks after exposure to a rich or complex medium.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gomez, R. F., Sinskey, A. J., Davies, R., and Labuza, T. P., J. gen. Microbiol., 74, 267 (1973).
Gomez, R. F., and Sinskey, A. J., J. Bact., 115, 522 (1973).
Bridges, B. A., Ashwood-Smith, M. J., and Munson, R. J., J. gen. Microbiol., 58, 115 (1969).
Bridges, B. A., Ashwood-Smith, M. J., and Munson, R. J., Biochem. biophys. Res. Commun., 35, 193 (1969).
Woodcock, E., and Grigg, G. W., Nature new Biol., 237, 76 (1972).
Sedgwick, S. G., and Bridges, B. A., J. gen. Microbiol., 71, 191 (1972).
Goldmark, D. J., and Linn, S., Proc. natn. Acad. Sci. U.S.A., 67, 434 (1970).
Verly, W. G., Paquette, Y., and Thibodeau, L., Nature new Biol., 244, 67 (1973).
Chamberlin, M., and Berg, P., Cold Spring Harbor Symp. quant. Biol., 28, 67 (1973).
Chen, C. Y., Hutchison, C. A., III, and Edgell, M. H., Nature new Biol., 243, 233 (1973).
Umezawa, H., Mizuno, S., Yamazaki, H., and Nitta, K., J. Antibiot., 21, 234 (1968).
Wehrli, W., and Staehelin, M., Bact. Rev., 35, 290 (1971).
Boyce, R. P., and Setlow, R. B., Biochim. biophys. Acta, 16, 618 (1962).
Tremblay, G. H., Daniels, M. J., and Schaechter, M., J. molec. Biol., 40, 65 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GOMEZ, R., SINSKEY, A. DNA Breaks in Rifampin-treated Salmonella typhimurium LT2 after Exposure to Nutritionally Complex Media. Nature 247, 211–212 (1974). https://doi.org/10.1038/247211a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/247211a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.