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Increase in Kallikrein Excretion during the Natriuresis produced by Arterial Infusion of Substance P

Nature volume 247, pages 108–109 (1974)Cite this article

Abstract

SUBSTANCE P was discovered by von Euler and Gaddum in 1931 in extracts of brain and small intestine1 and its distribution and effects have recently been reviewed2. Its structure has been identified3 and the undecapeptide has recently been synthesised4. Substance P is a potent stimulator of salivary secretion5; stimulation of the chorda-lingual nerve leads to increases in the production of saliva and blood flow through the salivary gland and is associated with the depletion of glandular kalli-krein6. The presence of atropine blocks secretion but does not affect the increase in blood flow7 or kallikrein depletion6. In homogenised nervous tissue substance P is located in the fraction containing the synaptic vesicles8.

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Authors and Affiliations

  1. Department of Investigative Medicine, University of Cambridge, Downing Street, Cambridge, CB2 1QN

    IVOR H. MILLS, N. A. A. MACFARLANE & P. E. WARD

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  1. IVOR H. MILLS
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  2. N. A. A. MACFARLANE
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  3. P. E. WARD
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MILLS, I., MACFARLANE, N. & WARD, P. Increase in Kallikrein Excretion during the Natriuresis produced by Arterial Infusion of Substance P. Nature 247, 108–109 (1974). https://doi.org/10.1038/247108a0

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