Abstract
The binding of 3H-noradrenaline to intact cells and microsomes seems not to measure catecholamine receptor interactions, but rather a membrane catechol-binding protein which may be related to the enzyme, catechol-O-methyl transferase. True receptors are probably scarce and detection will require catecholamine derivatives of much higher specific activity than are at present available.
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Cuatrecasas, P., Tell, G., Sica, V. et al. Noradrenaline binding and the search for catecholamine receptors. Nature 247, 92–97 (1974). https://doi.org/10.1038/247092a0
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DOI: https://doi.org/10.1038/247092a0
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