Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Platelet Contractile Regulation in an Isometric System

A Corrigendum to this article was published on 01 August 1974

Abstract

WE have previously shown that human platelets, in addition to actomyosin, the so-called thrombosthenin1, contain a tropomyosin-like protein2. Furthermore, we provided evidence for the presence in isolated platelet actomyosin of a control system which “turns-on” the Mg-ATPase of the contractile protein complex at a saturating level of 10−6 M Ca2+ (ref. 2).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bettex-Galland, M., and Lüscher, E. F., Biochim. biophys. Acta, 49, 536 (1961).

    Article  CAS  Google Scholar 

  2. Cohen, I., and Cohen, C., J. molec. Biol., 68, 383 (1972).

    Article  CAS  PubMed  Google Scholar 

  3. Grette, K., Nature, 198, 488 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Statland, B. E., Heagan, B. M., and White, J. G., Nature, 223, 521 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Majno, G., Bouvier, C. A., Gabbiani, G., Ryan, G. B., and Statkov, P., Thromb. Diath. Haemorrh., 28, 49 (1972).

    Article  CAS  PubMed  Google Scholar 

  6. Budtz-Olsen, O. E., in Clot Retraction (Blackwell Scientific Publications, Oxford, 1951).

    Google Scholar 

  7. Lüscher, E. F., Vox Sang., 1, 133 (1956).

    Article  Google Scholar 

  8. Ireland, D. M., Biochem. J., 105, 857 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Holmsen, H., and Day, H. J., J. Lab. clin. Med., 75, 841 (1970).

    Google Scholar 

  10. Rodman, N. F., and Mason, R. G., Fedn. Proc., 26, 95 (1967).

    CAS  Google Scholar 

  11. Mürer, E. H., and Holme, R., Biochim. biophys. Acta, 222, 197 (1970).

    Article  PubMed  Google Scholar 

  12. White, J. G., Blood, 31, 604 (1968).

    CAS  PubMed  Google Scholar 

  13. Day, H. J., and Holmsen, H., Ser. Haematol., 4, 3 (1971).

    CAS  PubMed  Google Scholar 

  14. Booyse, F. M., and Rafelson, jun., M. E., Ser. Haematol., 4, 152 (1971).

    CAS  PubMed  Google Scholar 

  15. Salzman, E. W., Chambers, D. A., and Neri, L. L., Nature, 210, 167 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Chambers, D. A., Salzman, E. W., and Neri, L. L., Archs. Biochem. Biophys., 119, 173 (1967).

    Article  CAS  Google Scholar 

  17. Rossi, E. S., Blood, 34, 543 (1969).

    Google Scholar 

  18. Lüscher, E. F., Probst, E., and Bettex-Galland, M., Ann. N.Y. Acad. Sci., 201, 122 (1972).

    Article  ADS  PubMed  Google Scholar 

  19. Cohen, I., Bohak, Z., de Vries, A., and Katchalski, E., Eur. J. Biochem., 10, 388 (1969).

    Article  CAS  PubMed  Google Scholar 

  20. Baenziger, N. L., Brodie, G. N., and Majerus, P. W., Proc. natn. Acad. Sci. U.S.A., 68, 240 (1971).

    Article  ADS  CAS  Google Scholar 

  21. Jamieson, G. A., Fuller, N. A., Barber, A. J., and Lombart, C., Ser. Haematol., 4, 125 (1971).

    CAS  PubMed  Google Scholar 

  22. Singer, S. J., Ann. N.Y. Acad. Sci., 195, 16 (1972).

    Article  ADS  CAS  PubMed  Google Scholar 

  23. Singer, S. J., in Structure and Function of Biological Membranes (edit. by Rothfield, L. I.), 145 (Academic Press, New York, 1971).

    Book  Google Scholar 

  24. Rubalcava, B., Martinez de Munoz, D., and Gitler, C., Biochemistry, N.Y., 8, 2742 (1969).

    Article  CAS  Google Scholar 

  25. Vanderkooi, J., and Martonosi, A., Archs. Biochem. Biophys., 133, 153 (1969).

    Article  CAS  Google Scholar 

  26. White, J. G., Krivit, W., and Vernier, R. L., Blood, 25, 241 (1965).

    CAS  PubMed  Google Scholar 

  27. Johnson, S. A., Fredell, L., Shepard, J. A., Tebo, T. H., Chang, C., Pederson, H. J., and Van Horn, D. L., in Physiology of Hemostasis and Thrombosis (edit. by Johnson, S. A., and Seegers, W. H.), 44 (Thomas, Springfield, Ill., 1967).

    Google Scholar 

  28. Cohen, I., Kaminski, E., and de Vries, A., FEBS Lett. (in the press).

  29. Chaberek, S., and Martell, A. E., Organic Sequestering Agents (Wiley, New York, 1959).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

COHEN, I., DE VRIES, A. Platelet Contractile Regulation in an Isometric System. Nature 246, 36–37 (1973). https://doi.org/10.1038/246036a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/246036a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing