Abstract
INTERFERON exhibits a marked antitumour effect in mice inoculated with allogeneic or syngeneic transplantahle tumours1–3, but comparable interferon preparations did not affect the growth or development of newborn mice4. It is important from both a theoretical and a practical point of view to determine whether interferon can inhibit normal cell division in the animal. It has been shown that interferon preparations inhibited the multiplication of normal adult allogeneic spleen cells and syngeneic bone marrow cells injected into heavily X-irradiated mice5. Jahiel and his co-workers demonstrated that three interferon inducers, Newcastle disease virus (NDV), polyinosinicpolycytidylic acid and statolon, inhibited the mitbtic response of liver cells after partial hepatectomy6, but that administration of interferon itself did not inhibit this response7. Now that potent and relatively purified mouse interferon preparations are available, we have used this experimental system, and report here a marked inhibition by interferon of liver regeneration after partial hepatectomy.
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FRAYSSINET, C., GRESSER, I., TOVEY, M. et al. Inhibitory Effect of Potent Interferon Preparations on the Regeneration of Mouse Liver after Partial Hepatectomy. Nature 245, 146–147 (1973). https://doi.org/10.1038/245146b0
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DOI: https://doi.org/10.1038/245146b0
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