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Malignant Tumours of Liver and Lung in Rats fed Aminopyrine or Heptamethyleneimine together with Nitrite

Nature volume 244, pages 176–178 (1973)Cite this article

Abstract

SOME human cancer might be caused by nitrosamines formed in the gastrointestinal tract from nitrite in the food and secondary or tertiary amines ingested deliberately or incidentally1–3. This hypothesis was supported by experiments in which rats fed with nitrite and secondary amines developed the same type of tumours as after treatment with the respective nitrosamines4.

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Author information

Authors and Affiliations

  1. Carcinogenesis Program, Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, 37830

    W. LIJINSKY, H. W. TAYLOR, C. SNYDER & P. NETTESHEIM

Authors
  1. W. LIJINSKY
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  2. H. W. TAYLOR
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  3. C. SNYDER
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  4. P. NETTESHEIM
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LIJINSKY, W., TAYLOR, H., SNYDER, C. et al. Malignant Tumours of Liver and Lung in Rats fed Aminopyrine or Heptamethyleneimine together with Nitrite. Nature 244, 176–178 (1973). https://doi.org/10.1038/244176a0

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  • DOI: https://doi.org/10.1038/244176a0

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