Abstract
THIS study deals with classic ex-vivo, self-perfusing heart–lung preparations, in which the circulating medium is a pure human haemoglobin solution free of stroma. Although this scheme was first devised for preservation for subsequent transplantation, it also provides a convenient method of testing the effects of pharmacological agents on such preparations without interference from the figured elements of the blood for periods up to 6 h.
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RIEDESEL, W., ERDAMAR, I. & DOS, S. Functional Preservation of Canine Heart–Lung Preparations by Perfusion with Pure Haemoglobin Solution. Nature 243, 530–531 (1973). https://doi.org/10.1038/243530a0
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DOI: https://doi.org/10.1038/243530a0
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