Abstract
CARCINOEMBRYONIC antigens (CEA) are present in perchloric acid-soluble extracts of carcinoma of the gastrointestinal tract, particularly of the colon and rectum1. I report here some observations suggesting that CEA, as present in perchloric acid extracts of carcinomata, is an aggregate of cationic protein and metachromatic material.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gold, P., and Freedman, S. O., J. Exp. Med., 122, 467 (1965).
Martin, F., and Martin, M. S., Int. J. Cancer, 9, 641 (1972).
Coligan, J. E., Lautenschleger, J. T., Egan, M. L., and Todd, C. W., Immunochemistry, 9, 377 (1972).
Krupey, J., Wilson, T., Freedman, S. O., and Gold, P., Immunochemistry, 9, 617 (1972).
Pearse, A. G. E., Histochemistry (second ed.), 834 (Churchill, London, 1960).
Ornstein, L., Ann. NY Acad. Sci., 121, 321 (1964).
Eylar, E. H., Salk, J., Beveridge, G. C., and Brown, L. V., Arch. Biochem. Biophys., 132, 34 (1969).
Hagopian, A., and Eylar, E. H., Arch. Biochem. Biophys., 126, 785 (1968).
Banjo, C., Gold, P., Freedman, S. O., and Krupey, J., Nature New Biology, 238, 183 (1972).
Gold, J. M., Freedman, S. O., and Gold, P., Nature New Biology, 239, 60 (1972).
Dickinson, J. P., Caspary, E. A., and Field, E. J., Nature New Biology, 239, 181 (1972).
Field, E. J., and Caspary, E. A., Lancet, ii, 1337 (1970).
Caspary, E. A., and Field, E. J., Brit. Med. J., 2, 613 (1971).
Laico, M. T., Ruoslahti, E. I., Papermaster, D. S., and Dreyer, W. J., Proc. US Nat. Acad. Sci., 67, 120 (1970).
Gold, P., Krupey, J., and Ansari, H., J. Nat. Cancer Inst., 45, 219 (1970).
Hirschfeld, J., Science Tools, 7, 18 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HUGHES, N. pH-Dependent Changes in Composition of Carcinoembryonic Antigen. Nature 243, 523–526 (1973). https://doi.org/10.1038/243523a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/243523a0
This article is cited by
-
Carcinofetale Antigene
Klinische Wochenschrift (1975)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
