Abstract
THE structures of more than 100 variant human haemoglobins have been determined and in many cases it has been possible to relate the position of the individual amino-acid substitution to the stability and function of the molecule1,2. Here we describe the amino-acid replacement, structural alterations and oxygenation properties of a variant, haemoglobin-Camden, which has a substitution in the α1β1 intersubunit contact of the haemoglobin molecule.
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References
Perutz, M. F., and Lehmann, H., Nature, 219, 902 (1968).
WHO Scientific Group, Tech. Rep. Ser., No. 509 (1972).
Bellingham, A. J., and Huehns, E. R., Nature, 218, 92 (1968).
Clegg, J. B., Naughton, M. A., and Weatherall, D., J. Mol. Biol., 19, 91 (1966).
Huehns, E. R., in Chromatographic and Electrophoretic Techniques, Part 1 (edit. by Smith, I.), 291 (Heinemann, London, 1968).
Jones, R. T., Cold Spring Harbor Symp. Quant. Biol., 29, 297 (1964).
Ambler, R. P., in Methods in Enzymology (edit. by Colowick, S. P., and Kaplan, N. O.), 11, 236 (Academic, New York and London, 1967).
Gray, W. R., in Methods in Enzymology (edit. by Colowick, S. P., and Kaplan, N. O.), 11, 139 (Academic, New York and London, 1967).
Perutz, M. F., Muirhead, H., Cox, J. M., and Goaman, L. C. G., Nature, 219, 131 (1968).
Huehns, E. R., in Textbook of Haematology (edit. by Hardisty, R. M., and Weatherall, D. J.) (Blackwell, Oxford, 1973).
Dayhoff, M. O., Atlas of Protein Sequence and Structure (National Biomedical Research Foundation, Georgetown University Medical Center, 1972).
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WADE COHEN, P., YATES, A., BELLINGHAM, A. et al. Amino-acid Substitution in the α1β1 Intersubunit Contact of Haemoglobin-Camden β131 (H9) Gln→Glu. Nature 243, 467–468 (1973). https://doi.org/10.1038/243467a0
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DOI: https://doi.org/10.1038/243467a0
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