Abstract
SUPERNATANTS of allogeneic lymphocyte cultures enable bone-marrow derived (lymphocytes) to respond to sheep red blood cells (SRBC) in vitro1–3. It was suggested that a non-specific T cell-dependent mediator may be involved in the normal immune response to this antigen. Indeed, T cells educated to one erythrocyte antigen can, in the presence of that antigen, greatly facilitate the response of B cells to other non-cross reacting erythrocytes4,5. T cells educated to protein antigens can also generate such a non-specific event in the interaction of T and B cells in vitro6. The following experiments were designed to establish whether in this syngeneic system the phenomenon was dependent on the production of soluble mediators after activation of T cells by protein antigen.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schimpl, A., and Wecker, E., Nature New Biology, 237, 15 (1972).
Feldmann, M., and Basten, A., J. Exp. Med., 136, 722 (1972).
Hartmann, K. U., J. Exp. Med., 133, 1325 (1971).
Hunter, P., Munro, A., and McConnell, I., Nature, 236, 52 (1972).
Waldmann, H., Munro, A., and Hunter, P., Europ. J. Immunol., 3, 167 (1973).
Marbrooke, J., Lancet, ii, 1279 (1967).
Feldmann, M., and Basten, A., Nature New Biology, 237, 12 (1972).
Mishell, R. I., and Dutton, R. W., J. Exp. Med., 126, 423 (1967).
Click, R. E., Benck, L., and Alter, B. J., Cell. Immunol., 3, 264 (1972).
Golub, E. S., Cell. Immunol., 2, 353 (1971).
Feldmann, M., J. Exp. Med., 136, 757 (1972).
Gery, I., and Waksman, B. H., J. Exp. Med., 136, 143 (1972).
Katz, D. H., Paul, W. E., Goidl, E. A., and Benacerraf, B., J. Exp. Med., 133, 169 (1971).
Osborne, jun., D. P., and Katz, D. H., J. Exp. Med., 136, 439 (1972).
Ordal, J. C., and Grumet, F. C., J. Exp. Med., 136, 1195 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WALDMANN, H., MUNRO, A. T Cell-dependent Mediator in the Immune Response. Nature 243, 356–357 (1973). https://doi.org/10.1038/243356a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/243356a0
This article is cited by
-
Multiple thymus-derived helper cell activities involved in antibody responses
Survey of Immunologic Research (1982)
-
Cooperation across the histocompatibility barrier
Nature (1975)
-
T cell factor which can replace T cells in vivo
Nature (1974)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
