Abstract
LEAD has long been known to be toxic to animals and humans, with some of its effects being attributable to actions on the neuromuscular system1,2. Since several other polyvalent cations have potent effects on neuromuscular transmission3–19, the question arose as to whether one of the manifestations of lead toxicity might be an interference with neuromuscular transmission. Answers to this question might elucidate some mechanisms of lead toxicity and, at the same time, improve our understanding of junctional transmission. This report shows that lead influences both pre and postsynaptic events in neuromuscular transmission with the presynaptic ones being most sensitive.
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References
Cumings, J. N., Heavy Metals and the Brain, 95 (Thomas, Springfield, 1959).
Lead: Airborne Lead in Perspective, 84, 178 (National Academy of Sciences, Washington DC, 1972).
del Castillo, J., and Engbaek, L., J. Physiol., 124, 370 (1954).
Jenkinson, D. H., J. Physiol., 138, 434 (1957).
Dodge, jun., F. A., and Rahamimoff, R., J. Physiol., 193, 419 (1967).
Katz, B., The Release of Neural Transmitter Substances (Thomas, Springfield, Illinois, 1969).
Meiri, U., and Rahamimoff, R., J. Physiol., 215, 709 (1971).
Heuser, J., Katz, B., and Miledi, R., Proc. Roy. Soc., B 178, 407 (1971).
Blioch, Z. L., Glagoleva, I. M., Liberman, E. A., and Nenashev, V. A., J. Physiol., 199, 11 (1968).
Hubbard, J. I., J. Physiol., 159, 507 (1961).
del Castillo, J., and Katz, B., J. Physiol., 124, 553 (1954).
Mambrini, J., and Benoit, P. R., CR Acad. Sci. Paris, 158, 1454 (1964).
Lambert, D. H., and Parsons, R. L., J. Gen. Physiol., 56, 309 (1970).
DeBassio, W. A., Schnitzler, R. M., and Parsons, R. L., J. Neurobiol., 2, 263 (1971).
Heuser, J., and Miledi, R., Proc. Roy. Soc., B 179, 247 (1971).
Kajimoto, N., and Kirpekar, S. M., Nature New Biology, 235, 29 (1972).
Miledi, R., Nature, 212, 1233 (1966).
Benoit, P. R., and Mambrini, J., J. Physiol., 210, 681 (1970).
Meiri, U., and Rahamimoff, R., Science, 176, 308 (1972).
Kostial, K., and Vouk, V. B., Brit. J. Pharmacol., 12, 219 (1957).
Katz, B., and Miledi, R., Proc. Roy. Soc., B 161, 453 (1965).
Nastuk, W. L., Fed. Proc., 10, 96 (1951).
del Castillo, J., and Katz, B., J. Physiol., 128, 157 (1955).
Fatt, P., and Katz, B., J. Physiol., 117, 109 (1952).
del Castillo, J., and Katz, B., J. Physiol., 124, 560 (1954).
Quastel, D. M. J., Hackett, J. T., and Cooke, J. D., Science, 172, 1034 (1971).
Miledi, R., J. Physiol., 151, 1 (1960).
Feltz, A., and Mallart, A., J. Physiol., 218, 85 (1971).
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MANALIS, R., COOPER, G. Presynaptic and Postsynaptic Effects of Lead at the Frog Neuromuscular Junction. Nature 243, 354–356 (1973). https://doi.org/10.1038/243354a0
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DOI: https://doi.org/10.1038/243354a0
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