Contractile Effects of a Calcium Ionophore

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THE contractile state of muscle is controlled through variations of the intracellular concentration of calcium ion1–3. In different types of muscle, Ca2+ transients inside the fibres are sustained to various degrees by calcium movements to and from intracellular stores, such as the sarcoplasmic reticulum (SR). In skeletal muscle, the activity of SR is sufficient to account for release and uptake of intracellular calcium, fulfilling concentration and time requirements for a single twitch. But it is not as well developed in cardiac and even less so in smooth muscle.

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LEVY, J., COHEN, J. & INESI, G. Contractile Effects of a Calcium Ionophore. Nature 242, 461–463 (1973) doi:10.1038/242461a0

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