Abstract
RESULTS of studies of transport in the nervous system using whole brain and slice preparations suffer from the disadvantage that it is not certain whether they apply to capillary, glial, and/or neuronal cells. Isolation of intact synaptic nerve endings (synaptosomes) has made it possible to investigate transport across synaptic membranes which are free of significant glial contamination1. Synaptosomes can respire and generate ATP and phosphocreatine with glucose as substrate, and glucose metabolism is largely abolished when synaptosomes are ruptured2. The data reported here suggest that carrier mediated sugar transport across synaptic membranes has different characteristics from that seen in brain and brain slices.
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DIAMOND, I., FISHMAN, R. High Affinity Transport of 2-Deoxyglucose in Isolated Synaptic Nerve Endings. Nature 242, 122–123 (1973). https://doi.org/10.1038/242122a0
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DOI: https://doi.org/10.1038/242122a0
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