Abstract
DNA replication can occur throughout the nucleus and is not restricted to the inner surface of the nuclear membrane.
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References
Jacob, F., Brenner, S., and Cuzin, F., Cold Spring Harbor Symp. Quant. Biol., 28, 329 (1963).
Ganesan, A. T., and Lederberg, J., Biophys. Biochem. Res. Commun., 18, 824 (1965).
Smith, D. W., and Hanawalt, P. C., Biochim. Biophys. Acta, 149, 519 (1967).
Tremblay, G. Y., Daniels, M. J., and Schaechter, M., J. Mol. Biol., 40, 65 (1969).
Sueoka, N., and Quinn, W. G., Cold Spring Harbor Symp. Quant. Biol., 33, 695 (1968).
Fuchs, E., and Hanawalt, P. C., J. Mol. Biol., 52, 301 (1970).
Fielding, P., and Fox, C. F., Biochem. Biophys. Res. Commun., 41, 157 (1970).
Friedman, D. F., and Mueller, G. C., Biochim. Biophys. Acta, 174, 253 (1969).
Mizuno, N. S., Stoops, C. D., and Sinha, A. A., Nature New Biology, 229, 22 (1971).
Hanaoka, F., and Yamada, M., Biochem. Biophys. Res. Commun., 42, 647 (1971).
Pearson, G. D., and Hanawalt, P. C., J. Mol. Biol., 62, 65 (1971).
Smith, B. J., J. Mol. Biol., 47, 101 (1970).
O'Brien, R. L., Sanyal, A. B., and Stanton, R. H., Exp. Cell Res., 70, 106 (1972).
Comings, D. E., and Kakefuda, T., J. Mol. Biol., 33, 225 (1968).
Blondel, B., Exp. Cell Res., 53, 348 (1968).
Williams, C. A., and Ockey, C. H., Exp. Cell Res., 63, 365 (1970).
Erlandson, R. A., and de Harven, E., J. Cell Sci., 8, 353 (1971).
Kay, R. R., Haines, M. E., and Johnston, I. R., FEBS Lett., 16, 233 (1971).
Huberman, J. A., and Riggs, A. D., J. Mol. Biol., 32, 327 (1968).
Caro, L. G., and Van Tubergen, R. P., J. Cell Biol., 15, 173 (1962).
Stubblefield, E., in Methods in Cell Physiology (edit. by Prescott, D. M.), 3, 25 (Academic Press, New York, 1968).
Ockey, C. H., Exp. Cell Res., 70, 203 (1972).
Tobia, A. M., Schildkraut, C. L., and Maio, J. J., Biochim. Biophys. Acta, 246, 258 (1971).
Bostock, C. J., and Prescott, D. M., Exp. Cell Res., 64, 267 (1971).
Flamm, W. G., Bernheim, N. J., and Brubaker, P. E., Exp. Cell Res., 64, 97 (1971).
Lima-de-Faria, A., and Javorska, H., Nature, 217, 138 (1968).
Brown, S. W., Science, 151, 417 (1966).
Fakan, S., Turner, G. N., Pagano, J. S., and Hancock, R., Proc. US Nat. Acad. Sci., 69, 2300 (1972).
Lenk, R., and Penman, S., J. Cell Biol., 49, 541 (1971).
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HUBERMAN, J., TSAI, A. & DEICH, R. DNA Replication Sites within Nuclei of Mammalian Cells. Nature 241, 32–36 (1973). https://doi.org/10.1038/241032a0
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DOI: https://doi.org/10.1038/241032a0
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