Abstract
PROTEIN molecules associated with membranes presumably are the keys to the mechanisms of a number of cell functions. For two membranes it has been suggested1 that some of the protein is embedded in a lipid bilayer. I present here evidence of two kinds, covering a wide variety of natural membranes, for molecules of protein each partly inserted in a lipid bilayer and partly exposed to the aqueous medium outside. This evidence generally rules out a normal lipid bilayer with all the protein outside.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wilkins, M. H. F., Blaurock, A. E., and Engelman, D. M., Nature New Biology, 230, 72 (1971).
Small, D. M., J. Lipid Res., 8, 551 (1967).
Luzzati, V., Reiss-Husson, F., Rivas, E., and Gulik-Krzywicki, T., Ann. NY Acad. Sci., 137, 409 (1966).
Levine, Y. K., and Wilkins, M. H. F., Nature New Biology, 230, 69 (1971).
Blaurock, A. E., J. Mol. Biol., 56, 35 (1971).
Caspar, D. L. D., and Kirschner, D. A., Nature New Biology, 231, 46 (1971).
“Myelin” Work SessionNeurosciences Res. Prog. Bull., 9, 440 (1971).
Blaurock, A. E., and Wilkins, M. H. F., Nature, 223, 906 (1969).
Blaurock, A. E., and Wilkins, M. H. F., Nature, 236, 313 (1972).
Oesterhelt, D., Blaurock, A. E., and Stoeckenius, W., Nature New Biology, 233, 149 (1971).
Engelman, D. M., J. Mol. Biol., 58, 153 (1971).
Blaurock, A. E., Chem. Phys. Lipids, 8, 285 (1972).
Danielli, J. F., and Davson, H., J. Cell Comp. Physiol., 5, 495 (1935).
Robertson, J. D., Biochem. Soc. Symp. (Cambridge), 16, 3 (1959).
Vanderkooi, G., and Sundaralingham, M., Proc. US Nat. Acad. Sci., 67, 233 (1970).
Blasie, J. K., Biophys. J., 12, 191 (1972).
Blaurock, A. E., Adv. Exp. Med. Biol., 24, 53 (1972).
Bigelow, C. C., J. Theoret. Biol., 16, 187 (1967).
Blaurock, A. E., Biophys. J. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BLAUROCK, A. Locating Protein in Membranes. Nature 240, 556–557 (1972). https://doi.org/10.1038/240556a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/240556a0
This article is cited by
-
Locating Protein in Membranes
Nature (1973)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.