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Lack of a relationship between the common 8q24 variant rs6983267 and risk of chronic lymphocytic leukemia

Leukemia volume 22, pages 438–439 (2008)Cite this article

B-cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia accounting for around 30% of all cases.1 Inherited predisposition to CLL is now well recognized, with epidemiological studies showing 3- to 7-fold elevations of risk in first-degree relatives of CLL cases.1 Part of this genetic risk is likely to be explained by combinations of common, lower-penetrance variants, making association studies an attractive means of identifying susceptibility alleles for CLL.

Recent studies have independently identified polymorphisms in the 8q24 region, including the single nucleotide polymorphism (rs6983267) to be strongly associated with risk of prostate2, 3, 4 and colorectal cancer,5 raising the possibility that 8q24 variants act as generic susceptibility alleles for neoplasia.

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Acknowledgements

We are grateful to the patients and their clinicians who participated in this study. This work was supported by grants from the Leukemia Research Fund and Cancer Research UK.

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Authors and Affiliations

  1. Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK

    G S Sellick, P Broderick, S Fielding & R S Houlston

  2. Section of Haemato-Oncology, Institute of Cancer Research, Sutton, Surrey, UK

    D Catovsky

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  1. G S Sellick
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  2. P Broderick
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  3. S Fielding
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  4. D Catovsky
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  5. R S Houlston
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Correspondence to R S Houlston.

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Sellick, G., Broderick, P., Fielding, S. et al. Lack of a relationship between the common 8q24 variant rs6983267 and risk of chronic lymphocytic leukemia. Leukemia 22, 438–439 (2008). https://doi.org/10.1038/sj.leu.2404915

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