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Cadmium-induced Testicular Injury and Alterations of Androgen Synthesis in Brook Trout

Abstract

NON-LETHAL doses of cadmium salts can cause specific injury to the testis of various mammalian species1,2. There is some evidence that the spermatogenic process can be adversely affected by Cd, possibly through its injurious effects on the vasculature of the testis3,4, but little is known of the effects of Cd on androgen synthesis5. In view of the well-documented reports of a direct relationship between androgens and maintenance of spermatogenesis in several vertebrate species including fish6 we investigated the effects of Cd on the testis of a freshwater-maintained salmonid fish, the brook trout Salvelinus fontinalis.

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SANGALANG, G., O'HALLORAN, M. Cadmium-induced Testicular Injury and Alterations of Androgen Synthesis in Brook Trout. Nature 240, 470–471 (1972). https://doi.org/10.1038/240470a0

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