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The PU.1 transcription factor induces cyclin D2 expression in U937 cells

Leukemia volume 20, pages 2208–2210 (2006)Cite this article

The PU.1 transcription factor is expressed in a wide variety of haematopoietic precursors including long-and short-term reconstituting stem cells, the common myeloid and lymphoid progenitors (CMP, CLP), granulocyte–monocyte progenitors (GMP), monocytes, neutrophils and B-lymphocytes. Compelling evidence gathered from both mouse models and human studies has demonstrated that PU.1 is a pivotal component of the intricate network regulating normal and neoplastic haematopoiesis.1

Physiologically, PU.1 expression contributes to the commitment of the CMPs to granulocytes and monocytes and to B-cell differentiation. These observations derive from studies on PU.1 knockout mice showing that PU.1-null animals present normal erythroid and megakaryocytic cells, but display embryonic/newborn lethality owing to the lack of monocytes, neutrophils and B-lymphocytes.2 More recently, the role of PU.1 in normal haematopoiesis has been further defined by conditional knockout mice demonstrating that PU.1 expression is critical to perpetuate the haematopoietic stem cell pool and to allow the generation of CMPs and CLPs.3 PU.1 disruption in CMPs or GMPs blocks their maturation, whereas PU.1 deficiency in CLPs does not affect their ability to differentiate in mature B cells. These results are not surprising considering that PU.1 induces the expression of multiple proteins critically involved in the commitment of the myeloid and lymphoid lineages, including the granulocyte/macrophage colony-stimulating factor receptor (CSF), the macrophage CSF receptor, the granulocyte CSF receptor and the interleukin-7 receptor.1

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Authors and Affiliations

  1. Dipartimento di Oncologia Sperimentale, Istituto Oncologico del Mediterraneo, Viagrande, Italy

    L Vicari, G Iannolo & R De Maria

  2. Dipartimento di Scienze Biomediche, Università di Catania, Catania, Italy

    L Vicari, L Manzella, L Malaguarnera, A Messina & P Vigneri

  3. Dipartimento di Ematologia, Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Roma, Italy

    A Eramo & R De Maria

  4. IOM Ricerca srl, Viagrande, Catania, Italy

    M Gulisano

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  1. L Vicari
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  9. P Vigneri
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Correspondence to P Vigneri.

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Vicari, L., Eramo, A., Manzella, L. et al. The PU.1 transcription factor induces cyclin D2 expression in U937 cells. Leukemia 20, 2208–2210 (2006). https://doi.org/10.1038/sj.leu.2404447

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