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Aberrant somatic hypermutation in primary mediastinal large B-cell lymphoma

Leukemia volume 19, pages 2363–2366 (2005)Cite this article

TO THE EDITOR

Primary mediastinal large B-cell lymphoma (PMLBCL) is recognized as a subtype of diffuse large B-cell lymphoma (DLBCL) arising in the mediastinum.1 However, the clinical, morphological and molecular peculiarities of PMLBCL have been taken to suggest that the disease may represent a distinct clinico-pathologic entity. Clinically, PMLBCL patients display younger median age (35 vs 60 years) and a higher female:male ratio when compared to DLBCL. Also, PMLBCL rarely has extra-thoracic disease at diagnosis, and at relapse preferentially involves extranodal sites.2 Pathologically, PMLBCL is typically associated with various degrees of sclerosis and consists of a diffuse proliferation of large cells expressing B-lineage markers but lacking surface immunoglobulins.1, 2 At the molecular level, PMLBCL exhibits several genetic abnormalities, including gains of 9p and X that are otherwise absent in DLBCL, and lack genetic lesions, such as BCL-2 and BCL-6 rearrangements that are typically associated with DLBCL.2

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Acknowledgements

This study has been supported by Ricerca Sanitaria Finalizzata and Ricerca Scientifica Applicata, Regione Piemonte, Torino, Italy; PRIN 2005 – MIUR, Rome, Italy; Istituto Superiore di Sanità, Programma Nazionale di Ricerca sull'AIDS – Progetto Patologia, Clinica e Terapia dell'AIDS, Rome, Italy; AIRC, Milan, Italy; and Novara-AIL Onlus, Novara, Italy. EB has been supported by Fondazione ‘Piera Pietro Giovanni Ferrero’, Alba, Italy. LP is a special fellow of the Leukemia & Lymhpoma Society.

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Authors and Affiliations

  1. Division of Hematology, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy

    D Rossi, M Cerri, D Capello, C Deambrogi, E Berra, S Franceschetti & G Gaidano

  2. Division of Oncology, Department of Medical Sciences & IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy

    O Alabiso

  3. Department of Oncology, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy

    O Alabiso

  4. Division of Pathology, IRCCS-Centro di Riferimento Oncologico, Aviano, Italy

    A Gloghini

  5. Institute of Pathology, University of Pavia, Pavia, Italy

    M Paulli

  6. Department of Pathology, Istituto Nazionale Tumori, Milano, Italy

    A Carbone

  7. Institute of Hematology and Oncology ‘L & A Seràgnoli’, University of Bologna, Bologna, Italy

    S A Pileri

  8. Institute for Cancer Genetics, Columbia University, New York, NY, USA

    L Pasqualucci

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  1. D Rossi
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  2. M Cerri
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  3. D Capello
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  13. G Gaidano
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Corresponding author

Correspondence to G Gaidano.

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Rossi, D., Cerri, M., Capello, D. et al. Aberrant somatic hypermutation in primary mediastinal large B-cell lymphoma. Leukemia 19, 2363–2366 (2005). https://doi.org/10.1038/sj.leu.2403982

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  • DOI: https://doi.org/10.1038/sj.leu.2403982

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