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Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib

Leukemia volume 19, pages 1851–1853 (2005)Cite this article

TO THE EDITOR

The pivotal role of phosphatidylinositol 3 kinase (PI3K) in signalling for the survival, proliferation and differentiation of normal hematopoietic progenitor cells is now clear. In fact, mice which do not express the hematopoietic-specific SH2-containing inositol 5 phosphatase establish a fundamental role for regulation of PtdIns(3,4,5)P3 metabolism in myelopoiesis in that they suffer from a myeloproliferative disorder.1

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Acknowledgements

This work was supported by the UK and NI Leukaemia Research Funds and the MRC. HG Hamzah is the recipient of a Borno State Scholarship, Federal Republic of Nigeria.

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Authors and Affiliations

  1. Faculty of Medicine, University of Manchester, Christie Hospital, Wilmslow Road, Manchester, UK

    H G Hamzah, A Pierce, E Spooncer & A D Whetton

  2. Department of Clinical Haematology, Manchester Royal Infirmary, Manchester, UK

    W A Stewart

  3. School of Life Sciences, University of Dundee, Dundee, UK

    C Peter Downes & A Gray

  4. Department of Haematology, University floor, Belfast City Hospital, Belfast, UK

    A Irvine

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  1. H G Hamzah
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  2. A Pierce
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  3. W A Stewart
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Correspondence to A D Whetton.

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Hamzah, H., Pierce, A., Stewart, W. et al. Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib. Leukemia 19, 1851–1853 (2005). https://doi.org/10.1038/sj.leu.2403919

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  • DOI: https://doi.org/10.1038/sj.leu.2403919

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