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NK cell subsets and CD107a mobilization assay

Leukemia volume 19, pages 1849–1851 (2005)Cite this article

TO THE EDITOR

We read with interest, in a recent issue of Leukemia, the paper by Penack et al1 about the validation of CD107a as a functional marker for natural killer (NK) cell activity. As in cytotoxic T cells, CD107a was shown by flow cytometry to be expressed at the cell surface as a consequence of degranulation of lytic granules, it was of course very interesting to check if this molecule would also appear on NK cells, another cytotoxic lymphocyte subset, upon target cell encounter. Indeed, the authors describe that after a few hours of incubation with the prototype NK cell target, the HLA class I-deficient myeloid leukemia cell line K562, up to 6% of fresh peripheral blood CD56+ cells are CD107a+, in contrast to 0% in the absence of target cells, as assessed by flow cytometry.

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References

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Authors and Affiliations

  1. Laboratoire d'Immunogénétique-Allergologie, Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg

    J Zimmer & F Hentges

  2. Service de Médecine Interne, Clinique Médicale B, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

    E Andrès

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  1. J Zimmer
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  2. E Andrès
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  3. F Hentges
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Correspondence to J Zimmer.

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Zimmer, J., Andrès, E. & Hentges, F. NK cell subsets and CD107a mobilization assay. Leukemia 19, 1849–1851 (2005). https://doi.org/10.1038/sj.leu.2403906

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