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VEGF-induced survival of chronic lymphocytic leukemia is independent of Bcl-2 phosphorylation

Leukemia volume 19, pages 1486–1487 (2005)Cite this article

TO THE EDITOR

A variety of studies have demonstrated that bone marrow stromal cells play an important role in regulating acute lymphoblastic leukemia (ALL)1 and chronic lymphocytic leukemia (CLL) cell survival and response to chemotherapy.2, 3 The significance of the microenvironment in CLL, along with new insights into its pathogenesis, has been extensively reviewed.4 While the importance of the bone marrow microenvironment in leukemic progression is not disputed, several details of the survival pathways initiated by bone marrow stromal cells remain under investigation.

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Acknowledgements

This work was supported in part by NIH Grant R01-HL056888 (LFG) and a WVU PSCoR grant (LFG).

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Authors and Affiliations

  1. Department of Pediatrics, Robert C., Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, WV, USA

    L Wang, J M Fortney & L F Gibson

  2. Department of Pathology, Robert C., Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, WV, USA

    J E Coad

  3. Department of Microbiology, Immunology, and Cell Biology, Robert C., Byrd Health Sciences Center, West Virginia University, School of Medicine, Morgantown, WV, USA

    L F Gibson

  4. Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University, School of Medicine, Morgantown, WV, USA

    L F Gibson

Authors
  1. L Wang
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Correspondence to L F Gibson.

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Wang, L., Coad, J., Fortney, J. et al. VEGF-induced survival of chronic lymphocytic leukemia is independent of Bcl-2 phosphorylation. Leukemia 19, 1486–1487 (2005). https://doi.org/10.1038/sj.leu.2403837

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