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Absence of ATM hypermethylation in mantle cell and follicular lymphoma

Leukemia volume 19, pages 880–882 (2005)Cite this article

TO THE EDITOR

Mantle cell lymphoma (MCL) and follicular lymphoma (FL) are two forms of B-cell lymphoma derived from neoplastic transformation of their normal counterparts in the mantle zone and germinal center, respectively.1 MCL is characterized in virtually all cases by t(11;14), with dysregulation of the cell cycle by upregulation of cyclin D1 located at 11q13.1 On the other hand, FL is characterized by t(14;18) and upregulation of BCL-2 located at 18q21, which confers resistance to apoptosis on the malignant lymphoid cells.1

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Acknowledgements

We express our sincere thanks to all medical and nursing staff in the Department of Medicine, Queen Mary Hospital, for the provision of expert medical care. This project was supported by a CRCG grant of the University of Hong Kong.

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Authors and Affiliations

  1. University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong

    C S Chim

  2. Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong

    K Y Wong, F Loong & G Srivastava

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  1. C S Chim
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Correspondence to C S Chim.

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Chim, C., Wong, K., Loong, F. et al. Absence of ATM hypermethylation in mantle cell and follicular lymphoma. Leukemia 19, 880–882 (2005). https://doi.org/10.1038/sj.leu.2403676

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