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CTLA-4 overexpression in CD19+/CD5+ cells correlates with the level of cell cycle regulators and disease progression in B-CLL patients

Leukemia volume 19, pages 301–304 (2005)Cite this article

TO THE EDITOR

The gradual accumulation of malignant cells in B-CLL is probably due to disturbances in the balance between programmed cell death and cell proliferation. It has been recently suggested that inhibitory CTLA-4 (cytotoxic T lymphocyte-associated antigen 4; CD152) molecule may be involved in the cell cycle machinery;1, 2 however, the role of CTLA-4 in cell cycle progression is relatively well understood in T cells only. CTLA-4 seems to prolong the progression through the G1 phase of the cell cycle by upregulation of cyclin D2 and inhibition of cyclin D3, cdk4, and cdk6 production.1, 2 CTLA-4 also affects the degradation of cyclin-dependent kinase inhibitor p27KIP1 and contributes to its earlier and stronger re-expression during the late stages of T-cell activation.1, 2 As little is known about CTLA-4 expression/function in normal and neoplastic B cells, we have extended our previous study concerning G1 cell cycle phase regulators in B-CLL cells3 in the context of their association with the expression of CTLA-4.

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Acknowledgements

The work was supported in part by Grant no. 4PO5B 136 18 from the State Committee for Scientific Research (KBN), Poland.

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Author notes

  1. A Kosmaczewska and L Ciszak: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wroclaw, Poland

    A Kosmaczewska, L Ciszak, K Suwalska & I Frydecka

  2. Department of Hematology, Medical University of Wroclaw, Pasteura 4, Wroclaw, Poland

    D Wolowiec & I Frydecka

Authors
  1. A Kosmaczewska
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  2. L Ciszak
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  3. K Suwalska
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  4. D Wolowiec
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  5. I Frydecka
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Correspondence to I Frydecka.

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Kosmaczewska, A., Ciszak, L., Suwalska, K. et al. CTLA-4 overexpression in CD19+/CD5+ cells correlates with the level of cell cycle regulators and disease progression in B-CLL patients. Leukemia 19, 301–304 (2005). https://doi.org/10.1038/sj.leu.2403588

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