Abstract
The recombinant urate oxidase, rasburicase (Elitek™, Sanofi-Synthelabo, Inc.), has recently received regulatory approval for the prevention and treatment of hyperuricemia in children with leukemia, lymphoma, and solid tumors. Prior to approval, 682 children and 387 adults in the US and Canada received rasburicase on compassionate-use basis. Uric acid concentration declined rapidly in both adult and pediatric patients after rasburicase treatment. Similar responses were observed in patients treated with subsequent courses. Possible drug-related adverse events, including allergic reactions, were uncommon. These data confirm that rasburicase is effective and safe for the treatment and prophylaxis of children and adults with malignancy-associated hyperuricemia.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Pui C-H . Introduction – optimal treatment of malignancies associated with hyperuricemia. Semin Hematol 2001; 38 (Suppl 10): 1–3.
Jeha S . Tumor lysis syndrome. Semin Hematol 2001; 38 (Suppl 10): 4–8.
Baecksgaard L, Sorensen JB . Acute tumor lysis syndrome in solid tumors – a case report and review of the literature. Cancer Chemother Pharmacol 2003; 51: 187–192.
Stapleton FB, Strother DR, Roy III S, Wyatt RJ, McKay CP, Murphy SB . Acute renal failure at onset of therapy for advanced stage Burkitt lymphoma and B cell acute lymphoblastic lymphoma. Pediatrics 1988; 82: 863–869.
Bowman WP, Shuster JJ, Cook B, Griffin T, Behm F, Pullen J et al. Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small non-cleaved cell lymphoma: a Pediatric Oncology Group Study. J Clin Oncol 1996; 14: 1252–1261.
Krakoff IH, Meyer RL . Prevention of hyperuricemia in leukemia and lymphoma: use of allopurinol, a xanthine oxidase inhibitor. JAMA 1965; 193: 89–94.
DeConti RC, Calabresi P . Use of allopurinol for the prevention and control of hyperuricemia in patients with neoplastic disease. N Engl J Med 1966; 274: 481–486.
Greene ML, Fujimoto WY, Seegmiller JE . Urinary xanthine stones – a rare complication of allopurinol therapy. New Engl J Med 1969; 280: 426–427.
Band PR, Silverberg DS, Henderson JF, Ulan RA, Wensel RH, Banerjee TK et al. Xanthine nephropathy in a patient with lymphosarcoma treated with allopurinol. N Engl J Med 1970; 283: 354–357.
Andreoli SP, Clark JH, McGuire WA, Bergstein JM . Purine excretion during tumor lysis in children with acute lymphocytic leukemia receiving allopurinol: relationship to acute renal failure. J Pediatr 1986; 109: 292–298.
Pui C-H . Rasburicase: a potent uricolytic agent. Expert Opin Pharmacother 2002; 3: 433–452.
Pui C-H, Relling MV, Lascombes F, Harrison PL, Struxiano A, Mondesir JM et al. Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies. Leukemia 1997; 11: 1813–1816.
Pui C-H, Mahmoud HH, Wiley JM, Woods GM, Leverger G, Camitta B et al. Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients with leukemia or lymphoma. J Clin Oncol 2001; 19: 697–704.
Goldman S, Holcenberg JS, Finklestein JZ, Hutchison R, Kreissman S, Johnson FL et al. A randomized comparison between rasburicase and allopurinol in children with lymphoma and leukemia at high risk of tumor lysis. Blood 2001; 97: 2998–3003.
Bosly A, Sonnet A, Pinkerton CR, McCowage G, Bron D, Sanz MA et al. Rasburicase (Recombinant Urate Oxidase) for the management of hyperuricemia in patients with cancer – report of an International Compassionate Use Study. Cancer 2003; 98: 1048–1054.
Pui C-H, Jeha S, Irwin D, Camitta B . Recombinant urate oxidase (rasburicase) in the prevention and treatment of malignancy-associated hyperuricemia in pediatric and adult patients: results of a compassionate-use trial. Leukemia 2001; 15: 1505–1509.
Van den Berg H, Reintsema AM . Renal tubular damage in rasburicase: risks of alkalinisation. Ann Oncol 2004; 15: 175–176.
Choukair MK . Blood chemistries/body fluids. In: Siberry GK, Iannone R (eds). The Harriet Lane Handbook: A Manual for Pediatric House Officers, 15th edn. St Louis: Mosby-Year Book Inc, 1996, pp 119–130.
Patte C, Sakiroglu C, Ansoborlo S, Baruchel A, Plouvier E, Pacquement H et al. Urate oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia treated in the Societe Francaise d'Oncologie Pediatrique LMB89 protocol. Ann Oncol 2002; 13: 789–795.
Atra A, Gerard M, Hobson R, Imeson J, Ashley S, Pinkerton C . Improved cure rate in children with B-cell acute lymphoblastic leukemia (B-ALL) and stage IV B-cell non-Hodgkin's lymphoma (B-NHL) – results of the UKCCSG 9003 protocol. Br J Cancer 1998; 77: 2281–2285.
Acknowledgements
This work was supported in part by grant CA-21765 from the National Cancer Institute, a grant from Sanofi-Synthelabo, Inc., a Center of Excellence grant from the State of Tennessee and American Lebanese Syrian Associated Charities (ALSAC). C-H Pui is the American Cancer Society FM Kirby Clinical Research Professor.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jeha, S., Kantarjian, H., Irwin, D. et al. Efficacy and safety of rasburicase, a recombinant urate oxidase (Elitek™), in the management of malignancy-associated hyperuricemia in pediatric and adult patients: final results of a multicenter compassionate use trial. Leukemia 19, 34–38 (2005). https://doi.org/10.1038/sj.leu.2403566
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2403566
Keywords
This article is cited by
-
Safety and Effectiveness of Rasburicase in the Control of Hyperuricemia in Pediatric Patients with Non-Hodgkin’s Lymphoma and Acute Leukemia: An Open-Label, Single-Arm, Multi-center, Interventional Study
Drugs in R&D (2023)
-
Rasburicase-induced hemolytic anemia and methemoglobinemia: a systematic review of current reports
Annals of Hematology (2023)
-
Guidelines for treatment of renal injury during cancer chemotherapy 2016
Clinical and Experimental Nephrology (2018)