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Lymphomas

Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas

Leukemia volume 18, pages 1711–1716 (2004)Cite this article

Abstract

A link between chronic hepatitis C virus (HCV) infection and low-grade B-cell lymphomas has been suggested by epidemiological studies. Marginal zone lymphomas (MZLs) including splenic lymphomas with villous lymphocytes are among the most frequently reported subgroups in the setting of chronic HCV infection. In this study, we examined the effect of antiviral treatment in eight patients with HCV-associated MZL. We found that five out of eight patients have responded to interferon alpha and ribavirin. In some cases, hematologic responses were correlated to virologic responses. In addition, we report a case of large granular lymphocyte leukemia occurring in association with MZL and HCV, and responding to interferon and ribavirin. We suggest that there is an etiologic link between HCV and antigen-driven lymphoproliferative disorders.

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Acknowledgements

We are grateful to Ms Phyllis Bazinet for her assistance in editing this paper.

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Authors and Affiliations

  1. Department of Hematology, Hôpital Cochin, Université Paris V, Assistance Publique Hôpitaux de Paris, Paris, France

    C Kelaidi, S Park, D Bouscary & F Dreyfus

  2. Department of Internal Medicine II, Hôpital Cochin, Université Paris V, Assistance Publique Hôpitaux de Paris, Paris, France

    F Rollot & P Blanche

  3. Department of Pathological Anatomy, Hôpital Cochin, Université Paris V, Assistance Publique Hôpitaux de Paris, Paris, France

    M Tulliez

  4. Department of Internal Medicine I, Hôpital Cochin, Université Paris V, Assistance Publique Hôpitaux de Paris, Paris, France

    B Christoforov

  5. Department of Surgery and Liver Transplantation, Hôpital Cochin, Université Paris V, Assistance Publique Hôpitaux de Paris, Paris, France

    Y Calmus

  6. Department of Hepato-gastroenterology, Hôpital Cochin, Université Paris V, Assistance Publique Hôpitaux de Paris, France

    P Podevin & P Sogni

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  1. C Kelaidi
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Correspondence to F Dreyfus.

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Kelaidi, C., Rollot, F., Park, S. et al. Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas. Leukemia 18, 1711–1716 (2004). https://doi.org/10.1038/sj.leu.2403443

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