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Novel technique to facilitate the rapid identification of CLL patients utilising the VH3–21 gene

Leukemia volume 18, page 872 (2004)Cite this article

TO THE EDITOR

Tobin et al1 has described a subset of patients with chronic lymphocytic leukaemia (CLL) using the VH3–21 gene. The majority of these cases also utilise the JH6 and Vλ2–14 gene segments, have 95–98% homology to germline IgVH gene sequence and have a poor prognosis irrespective of their mutational status.2 The same and other groups have noted biased usage of VH3–21 in association with JH63,4 and with VH–194 in mantle cell lymphoma. These cases have ⩾98% homology to the germline sequence and prolonged survival. A feature that appears unique to VH3–21 use in CLL is that these cases that utilise JH6 almost invariably have a short CDR3 and lack a D gene segment.

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Figure 1

References

  1. Tobin G, Thunberg U, Johnson A, Thorn I, Soderberg O, Hultdin M et al. Somatically mutated Ig V(H)3–21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002; 99: 2262–2264.

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Acknowledgements

This work has been supported by the ‘Wellcome Trust’ and the ‘Bournemouth Leukaemia fund’.

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Authors and Affiliations

  1. Department of Molecular Biology, Royal Bournemouth Hospital, Castle Lane East, Bournemouth, UK

    Z A Davis, R E Ibbotson & C M Wiseman

  2. Department of Haematology and Oncology, Royal Bournemouth Hospital, Castle Lane East, Bournemouth, UK

    D G Oscier

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  1. Z A Davis
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  2. R E Ibbotson
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  3. C M Wiseman
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  4. D G Oscier
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Correspondence to D G Oscier.

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Davis, Z., Ibbotson, R., Wiseman, C. et al. Novel technique to facilitate the rapid identification of CLL patients utilising the VH3–21 gene. Leukemia 18, 872 (2004). https://doi.org/10.1038/sj.leu.2403290

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