Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Reply to Gassas et al

Leukemia volume 17, page 2532 (2003)Cite this article

TO THE EDITOR

The purpose of our paper1 was to emphasize problems applying the WHO classification of myelodysplastic syndrome (MDS)2 in children, and to propose modifications of that classification, which were useful in pediatrics while retaining the basic similarity to the original WHO classification. Gassas et al3 criticize us for not differentiating myeloproliferative disorders (MPDs) from MDS in our paper. It was not our intention to present a comprehensive list of MPDs observed in children; therefore, we did not include CML, CNL, eosinophilic leukemia, etc., where the WHO classification is useful in children. We clearly stated, in our paper,1 that juvenile myelomonocytic leukemia (JMML) is a separate disorder and should not be included as MDS. JMML should also not be placed under the heading of MPD because of shared features with MDS that distinguish it from MPD. It is logically grouped with similar diseases such as chronic myelomonocytic leukemia and Ph(−) CML as myelodysplastic/myeloproliferative diseases, as in the WHO classification.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Hasle H, Niemeyer CM, Chessells JM, Baumann I, Bennett JM, Kerndrup G et al. A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases. Leukemia 2003; 17: 277–282.

    Article  CAS  Google Scholar 

  2. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001.

    Google Scholar 

  3. Gassas A, Freedman MH, Mandel K, Dror Y . Reply to Gassas et al. Leukemia 2003, in press.

  4. Mandel K, Dror Y, Poon A, Freedman MH . A practical, comprehensive classification for pediatric myelodysplastic syndromes: the CCC system. J Pediatr Hematol Oncol 2002; 24: 596–605.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Skejby Hospital, Aarhus, Denmark

    H Hasle

  2. University Children's Hospital, Freiburg, Germany

    C M Niemeyer

  3. Institute of Child Health, London, UK

    J M Chessells

  4. Institute of Pathology, Erlangen, Germany

    I Baumann

  5. University of Rochester Cancer Center, Rochester, USA

    J M Bennett

  6. Institute of Pathology, Odense University Hospital, Odense, Denmark

    G Kerndrup

  7. Department of Pathology, Vanderbilt University, Nashville, USA

    D R Head

Authors
  1. H Hasle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C M Niemeyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J M Chessells
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I Baumann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J M Bennett
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G Kerndrup
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D R Head
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hasle, H., Niemeyer, C., Chessells, J. et al. Reply to Gassas et al. Leukemia 17, 2532 (2003). https://doi.org/10.1038/sj.leu.2403166

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403166

Search

Advanced search

Quick links