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BRAF gene is not mutated in plasma cell leukemia and multiple myeloma

Leukemia volume 17, pages 2238–2240 (2003)Cite this article

TO THE EDITOR

The mitogen-activated protein kinase (MAPK) pathway is a highly conserved pathway that regulates proliferation, differentiation, survival and apoptosis in many eucaryote cells and organisms. Mutations of the genes encoding key components of MAPK pathway contribute to the development of several human cancers.1 RAF genes encode serine–threonine kinases, which transduce regulatory signals from RAS to MEK1/2. All RAF isoforms (RAF1, BRAF and ARAF) share RAS as a common upstream activator.2 Recently, great interest has grown about mutations in the BRAF gene that have been described in more than 60% of malignant melanomas, in 10% of colorectal cancers and in a small percentage of many other human tumors.3,4,5

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  1. Center for Experimental Research and Medical Studies (CERMS), University of Turin, Turin, Italy

    L Bonello, C Voena, M Ladetto, M Boccadoro, G Palestro, G Inghirami & R Chiarle

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  1. L Bonello
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  2. C Voena
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  3. M Ladetto
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  6. G Inghirami
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  7. R Chiarle
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Bonello, L., Voena, C., Ladetto, M. et al. BRAF gene is not mutated in plasma cell leukemia and multiple myeloma. Leukemia 17, 2238–2240 (2003). https://doi.org/10.1038/sj.leu.2403116

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