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Contrary to adult patients, expression of the multidrug resistance gene (MDR1) fails to define a poor prognostic group in childhood AML

Leukemia volume 17, pages 470–471 (2003)Cite this article

TO THE EDITOR

A major cause of treatment failure in patients with acute myeloid leukemia (AML) is the occurrence of resistance to structurally and functionally unrelated drugs, called multidrug resistance (MDR). Several mechanisms of drug resistance have been identified; one of these is the overexpression of adenosine triphosphate (ATP)-dependent membrane proteins that function as drug efflux pumps. The best-characterized drug efflux pump is the permeability-glycoprotein (P-gp) which is encoded by the MDR1 gene.1

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  1. University Children’s Hospital, Jena, Germany

    D Steinbach, S Furchtbar, W Sell, J Lengemann, J Hermann, F Zintl & A Sauerbrey

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  1. D Steinbach
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  2. S Furchtbar
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  3. W Sell
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  7. A Sauerbrey
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Steinbach, D., Furchtbar, S., Sell, W. et al. Contrary to adult patients, expression of the multidrug resistance gene (MDR1) fails to define a poor prognostic group in childhood AML. Leukemia 17, 470–471 (2003). https://doi.org/10.1038/sj.leu.2402806

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