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Co-existence of pseudo-Chediak–Higashi anomaly and double minutes containing C-MYC oncogene in three patients with AML M2

Leukemia volume 16, pages 152–154 (2002)Cite this article

Double minute chromosomes (dmins) have been reported in solid tumors, in the human myeloid cell line HL-60 and in 1–10% of patients with acute myeloid leukemia (AML).1 All AML cases have been adults, predominantly elderly patients with leukemia of varying French–American–British (FAB) types.2 C-MYC oncogene has been shown to be amplified in several but not all cases of AML with dmins and reported to be associated with chemotherapy resistance and disease aggressiveness.3 It has also been suggested that AML patients with normal karyotype and numerous dmins might respond better to treatment and have a better prognosis than patients with complex karyotype and few dmins.2 The role of C-MYC oncogene and relationship between dmins and other cytogenetic abnormalities in AML is poorly understood.3 Dmins have been suggested to represent a sign of disease progression rather than a primary malignant event due to observations of concomitant occurrence of dmins and trisomy of chromosomes 4 or 6 although AML cases with dmins as a sole cytogenetic abnormality have been reported.1,2

Pseudo-Chediak–Higashi anomaly can be found in different forms of AML although they are most frequent in acute promyelocytic leukemia. AML cases with pink or purple pseudo-Chediak–Higashi anomaly, with or without simultaneous occurrence of Auer rods are seldom observed.4 Electron microscopy of pseudo-Chediak–Higashi anomaly demonstrated that they are peroxidase positive granules with no obvious crystalline structure4 some of which contain membranous lamellae and in some tubular structure can be observed. Chromosomal aberrations have been reported in some cases but there are no reports of the simultaneous occurrence of pseudo-Chediak–Higashi anomaly and dmins.

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Acknowledgements

We thank K Heidling-Lindahl and K Tingström for excellent expertize in cytogenetic analysis. This work was supported by a grant from Cancerforskningsfonden in Umeå.

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Authors and Affiliations

  1. Medical Genetics, Norrlands University Hospital, Umeå, Sweden

    I Golovleva & G Holmgren

  2. Clinical Chemistry, Norrlands University Hospital, Umeå, Sweden

    J Hultdin

  3. Department of Medical Biosciences, Pathology, Norrlands University Hospital, Umeå, Sweden

    G Roos

  4. Department of Medicine, Hematology, Norrlands University Hospital, Umeå, Sweden

    A Wahlin

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Golovleva, I., Hultdin, J., Roos, G. et al. Co-existence of pseudo-Chediak–Higashi anomaly and double minutes containing C-MYC oncogene in three patients with AML M2. Leukemia 16, 152–154 (2002). https://doi.org/10.1038/sj.leu.2402323

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