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Heat shock proteins – modulators of apoptosis in tumour cells

Leukemia volume 14, pages 1161–1173 (2000)Cite this article

Abstract

Apoptosis is a genetically programmed, physiological method of cell destruction. A variety of genes are now recognised as positive or negative regulators of this process. Expression of inducible heat shock proteins (hsp) is known to correlate with increased resistance to apoptosis induced by a range of diverse cytotoxic agents and has been implicated in chemotherapeutic resistance of tumours and carcinogenesis. Intensive research on apoptosis over the past number of years has provided significant insights into the mechanisms and molecular events that occur during this process. The modulatory effects of hsps on apoptosis are well documented, however, the mechanisms of hsp-mediated protection against apoptosis remain to be fully defined, although several hypotheses have been proposed. Elucidation of these mechanisms should reveal novel targets for manipulating the sensitivity of leukaemic cells to therapy. This review aims to explain the currently understood process of apoptosis and the effects of hsps on this process. Several proposed mechanisms for hsp protection against apoptosis and the therapeutic implications of hsps in leukaemia are also discussed.

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Acknowledgements

We would like to acknowledge the Health Research Board of Ireland, Enterprise Ireland and the Children's Leukaemia Research Project for their financial support. We are also grateful to Dr RJ Carmody for the helpful comments and advice.

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  1. Department of Biochemistry, Tumour Biology Laboratory, University College Cork, Lee Maltings, Prospect Row, Cork, Ireland

    EM Creagh, D Sheehan & TG Cotter

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Creagh, E., Sheehan, D. & Cotter, T. Heat shock proteins – modulators of apoptosis in tumour cells. Leukemia 14, 1161–1173 (2000). https://doi.org/10.1038/sj.leu.2401841

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