Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Manuscript
  • Published:

Molecular Cytogenetics

Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia

Leukemia volume 11, pages 958–963 (1997)Cite this article

Abstract

Comparative genomic hybridization (CGH) was used to detect changes in DNA copy number in 25 cases of refractory acute myeloid leukemia (AML). CGH detected changes in DNA copy number in nine AML (36%). Losses (82%) were more frequent than gains (18%). No high-level amplifications were detected in any of the cases. Losses involved minimal overlapping regions at 5q14q32, 7q31.2q32 and 12p12. The most frequent gain was detected at 8q. CGH gave normal results in all cases with a normal karyotype or a translocation as the sole aberration. The absence of high-level DNA copy gains suggests that, in contrast to other malignancies, gene amplification is not an important mechanism for drug resistance in AML. In addition to 5q and 7q, known to be associated with disease refractoriness, 12p may be another region related to poor prognosis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland

    W El-Rifai, M Larramendy & S Knuutila

  2. Department of Human Genetics, National Research Centre, Cairo, Egypt

    W El-Rifai

  3. Department of Medicine, Helsinki University Central Hospital, Finland

    E Elonen & T Ruutu

  4. Laboratorio de Citogenética y Cátedra de Citología, Facultad de Ciencias Naturales, Universidad Nacional de La Plata, La Plata, Argentina

    M Larramendy

Authors
  1. W El-Rifai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E Elonen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M Larramendy
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T Ruutu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S Knuutila
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

El-Rifai, W., Elonen, E., Larramendy, M. et al. Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia. Leukemia 11, 958–963 (1997). https://doi.org/10.1038/sj.leu.2400706

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2400706

Keywords

This article is cited by

Search

Advanced search

Quick links