Attack Behaviour in Mice inhibited by Δ-9-Tetrahydrocannabinol


MARIJUANA and its active major ingredient, Δ-9-tetrahydrocan-nabinol (THC), reduce fighting among previously isolated mice1 and decrease preference for the side of a T-maze where they are rewarded by the opportunity to attack2. The degree of suppression of fighting behaviour seemed to be related to the cannabis resin content of the extract administered1. The behavioural effects which we reported2 could not be assessed for a THC dose-dependent relationship as some mice in the low-dosage group received faulty intravenous injections.

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KILBEY, M., FRITCHIE, G., MCLENDON, D. et al. Attack Behaviour in Mice inhibited by Δ-9-Tetrahydrocannabinol. Nature 238, 463–465 (1972).

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