Abstract
AN indirect estimate of monoamine oxidase (MAO) activity based on the formation of 14C-5-hydroxyindoleacetic acid from intravenously administered 14C-serotonin revealed no differences between schizophrenic patients and controls1. The important regulatory functions of monoamine oxidase in biogenic amine metabolism2, together with the evidence that MAO-inhibiting drugs may on occasion contribute to exacerbations of psychotic behaviour3, suggested, however, that direct examination of cellular MAO in schizophrenic patients might be of interest.
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MURPHY, D., WYATT, R. Reduced Monoamine Oxidase Activity in Blood Platelets from Schizophrenic Patients. Nature 238, 225–226 (1972). https://doi.org/10.1038/238225a0
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DOI: https://doi.org/10.1038/238225a0
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