Abstract
SMALL doses of ouabain have powerful central nervous depressant effects and induce hypothermia when administered into the cerebral ventricles of mice and rats1–3, in sharp contrast to the excitatory and convulsant effects produced by larger doses given centrally or peripherally in rodents2–5. To obtain further evidence that the depressant effects result from a direct action on the central nervous system we have used young chicks, in which adult blood-brain characteristics are not reported to be present until about the fourth week of life6,7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Doggett, N. S., Spencer, P. S. J., and Turner, T. A. R., Brit. J. Pharmacol., 40, 138P (1970).
Doggett, N. S., and Spencer, P. S. J., Brit. J. Pharmacol., 42, 242 (1971).
Doggett, N. S., thesis, Univ. Aston, Birmingham (1971).
Greef, K., and Kasperat, H., Arzneimittel-Forsch., 11, 908 (1961).
Greef, K., and Kasperat, H., Arch. Exp. Pathol. Pharmack., 242, 76 (1961).
Waelsch, H., in Biochemistry of the Developing Nervous System (edit. by Waelsch, H.), 187 (Academic Press, New York, 1955).
Dewhurst, W. G., in Principles of Psychopharmacology (edit. by Clarke, W. G., and del Giudice, J.), 111 (Academic Press, London, 1970).
Key, S. J., and Marley, E., Electroenceph. Clin. Neurophysiol., 14, 90 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DOGGETT, N., SPENCER, P. Ouabain and the Onset of the Blood-Brain Barrier in Neonate Chicks. Nature 237, 513–514 (1972). https://doi.org/10.1038/237513a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/237513a0
This article is cited by
-
The effect of ouabain and digitoxin on hexobarbitone sleeping time in the mouse
Psychopharmacologia (1975)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
