Abstract
ACETALDEHYDE (AcH) is the intermediary compound in the metabolic conversion of ethanol to acetate. Because AcH is a potent pharmacological agent in its own right, it has been the object of much recent investigational interest1,2. Many of the unpleasant symptoms observed in the alcohol-antabuse reaction have been attributed to acute increase of blood AcH3. It was suggested that barbiturate-induced increases in liver AcH dehydrogenase activity might contribute to the ethanol tolerance seen in persons who use barbiturates regularly4. Other properties of AcH, such as the release of catecholamines1 or the condensation with catecholamines to form tetrahydro-isoquinoline alkaloids5,6, may contribute to either the subjectively pleasant or unpleasant effects of alcoholic beverages.
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References
Truitt, E. B., and Walsh, M. J., in The Biology of Alcoholism, I, Biochemistry (edit. by Kissin, B., and Begleiter, H.) (Plenum, New York, 1971).
Sheppard, J. R., Albersheim, P., and McClearn, G., J. Biol. Chem., 245, 2876 (1970).
Hine, C. H., Burbridge, T. N., Macklin, E. A., Anderson, H. H., and Simon, A., J. Clin. Invest., 31, 317 (1952).
Redmond, G., and Cohen, G., Science, 171, 387 (1971).
Cohen, G., and Collins, M. A., Science, 167, 1749 (1970).
Yamanaka, Y., Walsh, M. J., and Davis, V. E., Nature, 227, 1143 (1970).
Freund, G., and O'Hollaren, P., J. Lipid Res., 6, 471 (1965).
Ridge, J. W., Biochem. J., 88, 95 (1963).
Axelrod, J., J. Pharmacol. Exp. Therap., 117, 322 (1965).
Kato, R., and Gillette, J. R., J. Pharmacol. Exp. Therap., 150, 279 (1965).
Conney, A. H., Pharmacol. Revs., 19, 317 (1967).
Rubin, E., and Lieber, C. S., Science, 172, 1097 (1971).
Lieber, C. S., and De Carli, L. M., J. Biol. Chem., 245, 2505 (1970).
Keilin, D., and Hartree, E. F., Biochem. J., 39, 293 (1945).
Adams, D. H., Biochem. J., 50, 486 (1952).
Adams, D. H., Brit. J. Cancer, 10, 748 (1956).
Maxwell, E. S., and Topper, Y. J., J. Biol. Chem., 236, 1032 (1961).
Ohno, S., Stenius, C., Christian, L., Harris, C., and Ivey, C., Biochem. Genet., 4, 565 (1970).
Sheppard, J. R., Albersheim, P., and McClearn, G. E., Biochem. Genet., 2, 205 (1968).
Cahalan, D., Cisin, I. S., and Crossley, H. M., in American Drinking Practices: A National Study of Drinking Behavior and Attitudes (Rutgers Center of Alcohol Studies, New Brunswick, New Jersey, 1969).
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REDMOND, G., COHEN, G. Biological Sciences: Sex Difference in Acetaldehyde Exhalation following Ethanol Administration in C57BL Mice. Nature 236, 117–119 (1972). https://doi.org/10.1038/236117a0
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DOI: https://doi.org/10.1038/236117a0
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