Abstract
Cis platinum (II) diammino-dichloride, cis Pt(II)(NH3)2Cl2 (A), is very effective against sarcoma 180 and leukaemia L 1210 in mice1,2 as well as Dunning ascites leukaemia and Walker 256 carcinosarcoma tumours in rats3. This and related compounds also reversibly inhibit cell division and induce cell elongation in E. coli B4,5. At a concentration below 5 µ, cis Pt(II)(NH3)2Cl2 selectively inhibits DNA synthesis in human amnion AV3 cells6, and there is a correlation between the relative effectiveness of a series of compounds and their capacity to inhibit DNA synthesis6. Support for the suggestion that in this cell line the effective platinum compounds acted by binding directly to DNA was obtained by Howie and Gale7. They found that DNA synthesis was selectively and persistently inhibited in Ehrlich ascites tumour cells removed from rats up to 4 days after treatment with a single injection of 10 mg/kg of A.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rosenberg, B., Van Camp, L., Trosko, J. E., and Mansour, V. H., Nature, 222, 385 (1969).
Rosenberg, B., and Van Camp, L., Cancer Res., 30, 1799 (1970).
Kociba, R. J., Sleight, S. D., and Rosenberg, B., Cancer Chem. Rep., Part I, 54, 325 (1970).
Rosenberg, B., Van Camp, L., Grimley, E. B., and Thomson, A. J., J. Biol. Chem., 242, 1347 (1967).
Rosenberg, B., Renshawe, E., Van Camp, L., Hartwick, J., and Drobnik, J., J. Bact., 93, 716 (1967).
Harder, H. C., and Rosenberg, B., Intern. J. Cancer, 6, 207 (1970).
Howle, J. A., and Gale, G. R., Biochem. Pharmacol., 19, 2757 (1970).
Ross, W. C. J., Biological Alkylating Agents (Butterworths, London, 1962).
Goldacre, R. J., Loveless, A., and Ross, W. C. J., Nature, 163, 667 (1949).
Brookes, P., and Lawley, P. D., Biochem. J., 80, 496 (1961).
Guiduschek, E. P., Proc. US Nat. Acad. Sci., 47, 900 (1965).
Kohn, K. W., Steigbigel, N. H., and Spears, C. L., Proc. US Nat. Acad. Sci., 53, 1154 (1965).
Levis, A. G., Danieli, G. A., and Piccinni, E., Nature, 207, 608 (1965).
Crathorn, A. R., and Roberts, J. J., Nature, 211, 150 (1966).
Roberts, J. J., Brent, T. P., and Crathorn, A. R., The Interaction of Drugs and Subcellular Components on Animal Cells (edit. by Campbell, P. N.), 5 (Churchill, London, 1968).
Ball, C. R., and Roberts, J. J., Chem. Biol. Interactions, 4, 297 (1971).
Roberts, J. J., Pascoe, J. M., Smith, B. A., and Crathorn, A. R., Chem. Biol. Interactions, 3, 49 (1971).
Lehmann, A. R., and Ormerod, M. G., Biochim. Biophys. Acta, 217, 268 (1970).
Kirby, K. S., and Cook, E. A., Biochem. J., 104, 254 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ROBERTS, J., PASCOE, J. Cross-linking of Complementary Strands of DNA in Mammalian Cells by Antitumour Platinum Compounds. Nature 235, 282–284 (1972). https://doi.org/10.1038/235282a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/235282a0
This article is cited by
-
Management of extravasation of oxaliplatin by mimicking its biotransformation
Clinical and Translational Oncology (2018)
-
Speciation and NMR Spectrometric Studies of Interaction of Di- and Tri-organotin(IV) Moieties with 5′-Guanosine Monophosphate and Guanosine in Aqueous Solution
Journal of Solution Chemistry (2014)
-
Solution Coordination Chemistry of Organotin(IV) Cations with Bio-relevant Ligands
Journal of Solution Chemistry (2012)
-
Triphenyltin(IV) 2-[(E)-2-(aryl)-1-diazenyl]benzoates as anticancer drugs: synthesis, structural characterization, in vitro cytotoxicity and study of its influence towards the mechanistic role of some key enzymes
Investigational New Drugs (2010)
-
Prevention of cisplatin nephrotoxicity: state of the art and recommendations from the European Society of Clinical Pharmacy Special Interest Group on Cancer Care
Cancer Chemotherapy and Pharmacology (2008)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.