Letter | Published:

Trickle Perfusion for Organ Preservation


THE two most successful methods of preserving canine kidneys are those described by Collins et al.1 and Belzer et al.2. In the Collins system, which is extremely simple, the organ is flushed with a solution (“Collins C4”) similar to intracellular fluid with a high potassium, phosphate and magnesium content. This solution is left in the kidney stored at 4° C, which will function well when re-implanted after 24 h. It is essential, however, that there should be no warm ischaemic damage to the kidney3. In Collins's experiments, the animals were very carefully maintained so that the kidneys were not maltreated until they were removed and rapidly cooled.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Collins, G. M., Bravo-Shugarman, M., and Terasaki, P. I., Lancet, ii, 1219 (1969).

  2. 2

    Belzer, F. O., Ashby, B. S., and Dunphy, J. E., Lancet, ii, 536 (1967).

  3. 3

    Frost, Ann B., Ackerman, J., Tyree Finch, W., and Manlove, A., Lancet, i, 620 (1970).

  4. 4

    Sinha, B. P., Atkinson, S. M., and Pierce, jun., J. M., Lancet, i, 421 (1971).

  5. 5

    Johnson, R. W. G., Morley, A., Swinney, J., and Taylor, R. M. R., Brit. J. Surg., 58, 299 (1971).

  6. 6

    Levy, M. V., Amer. J. Physiol., 197, 1111 (1959).

  7. 7

    Herrman, T. J., and Turcotte, J. G., Arch. Surg., 98, 121 (1969).

  8. 8

    Anderson, M., Shear, C. T. G., Murray, S., Swinney, J., and Taylor, R. M. R., Europ. Surg. Res., 3, 215 (1971).

  9. 9

    Calne, R. Y., Renal Transplantation, 31 (Edward Arnold, London, 1967).

  10. 10

    Calne, R. Y., Yoffa, D. E., White, H. J. O., and Maginn, R. R., Brit. J. Surg., 55, 203 (1968).

  11. 11

    Marshall, V. C., Ashby, B. S., Hadjiyannakis, E. J., and Lines, J., Brit. J. Surg., 57, 853 (1970).

  12. 12

    Schalm, S. W., Terpstra, J. L., Drayer, B., and Van Den Berg, C., Transplantation, 8, 877 (1969).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.