Letter | Published:

Trickle Perfusion for Organ Preservation

Abstract

THE two most successful methods of preserving canine kidneys are those described by Collins et al.1 and Belzer et al.2. In the Collins system, which is extremely simple, the organ is flushed with a solution (“Collins C4”) similar to intracellular fluid with a high potassium, phosphate and magnesium content. This solution is left in the kidney stored at 4° C, which will function well when re-implanted after 24 h. It is essential, however, that there should be no warm ischaemic damage to the kidney3. In Collins's experiments, the animals were very carefully maintained so that the kidneys were not maltreated until they were removed and rapidly cooled.

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References

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    Collins, G. M., Bravo-Shugarman, M., and Terasaki, P. I., Lancet, ii, 1219 (1969).

  2. 2

    Belzer, F. O., Ashby, B. S., and Dunphy, J. E., Lancet, ii, 536 (1967).

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    Anderson, M., Shear, C. T. G., Murray, S., Swinney, J., and Taylor, R. M. R., Europ. Surg. Res., 3, 215 (1971).

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    Calne, R. Y., Renal Transplantation, 31 (Edward Arnold, London, 1967).

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    Calne, R. Y., Yoffa, D. E., White, H. J. O., and Maginn, R. R., Brit. J. Surg., 55, 203 (1968).

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    Schalm, S. W., Terpstra, J. L., Drayer, B., and Van Den Berg, C., Transplantation, 8, 877 (1969).

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