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Unique High Affinity Uptake Systems for Glycine, Glutamic and Aspartic Acids in Central Nervous Tissue of the Rat

Abstract

NEUROPHYSIOLOGICAL experiments suggest that several aminoacids, especially glycine and glutamic, aspartic and gamma-aminobutyric (GABA) acids, are neurotransmitters in the central nervous system1–3. But careful subcellular4,5 and regional studies6–8 have not provided supporting neurochemical evidence, because ammo-acids, with the possible exception of GABA, also have general metabolic functions in nervous tissue.

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References

  1. 1

    Curtis, D. R., and Crawford, J. M., Ann. Rev. Pharmacol., 9, 209 (1969).

    CAS  Article  Google Scholar 

  2. 2

    Krnjevic, K., Nature, 228, 119 (1970).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Werman, R., Davidoff, R. A., and Aprison, M. H., J. Neurophysiol., 31, 81 (1968).

    CAS  Article  Google Scholar 

  4. 4

    Mangan, J. L., and Whittaker, V. P., Biochem. J., 98, 128 (1966).

    CAS  Article  Google Scholar 

  5. 5

    Kuhar, M. J., and Snyder, S. H., J. Pharmacol. Exp. Ther., 171, 141 (1970).

    CAS  Google Scholar 

  6. 6

    Aprison, M. H., and Werman, R., Life Sci., 4, 2075 (1965).

    CAS  Article  Google Scholar 

  7. 7

    Graham, L. T., Shank, R. P., Werman, R., and Aprison, M. H., J. Neurochem., 14, 465 (1967).

    CAS  Article  Google Scholar 

  8. 8

    Duggan, A. W., and Johnston, G. A. R., J. Neurochem., 17, 1205 (1970).

    CAS  Article  Google Scholar 

  9. 9

    Iversen, L. L., The Uptake and Storage of Noradrenaline in Sympathetic Nerves (Cambridge University Press, London, 1967).

    Google Scholar 

  10. 10

    Coyle, J. T., and Snyder, S. H., J. Pharmacol. Exp. Ther., 170, 221 (1969).

    CAS  PubMed  Google Scholar 

  11. 11

    Blackburn, K. J., French, P. C., and Merrills, R. M., Life Sci., 6, 1653 (1967).

    CAS  Article  Google Scholar 

  12. 12

    Shaskan, E. G., and Snyder, S. H., J. Pharmacol. Exp. Ther., 175, 404 (1970).

    CAS  PubMed  Google Scholar 

  13. 13

    Roberts, E., and Kuriyama, K., Brain Res., 8, 1 (1968).

    CAS  Article  Google Scholar 

  14. 14

    Iversen, L. L., and Neal, M. J., J. Neurochem., 15, 1141 (1968).

    CAS  Article  Google Scholar 

  15. 15

    Blasberg, R. G., in Prog. Brain Res. (edit. by Lajtha, A., and Ford, D. H.), 29, 245 (Elsevier, Amsterdam, 1968).

    Google Scholar 

  16. 16

    Lineweaver, H., and Burk, D., J. Amer. Chem. Soc., 56, 658 (1934).

    CAS  Article  Google Scholar 

  17. 17

    Cleland, W. W., Adv. Enzymol., 29, 1 (1967).

    CAS  PubMed  Google Scholar 

  18. 18

    Dixon, M., Biochem. J., 55, 170 (1953).

    CAS  Article  Google Scholar 

  19. 19

    Hammerschlag, R., Potter, L. T., and Vinci, J., Trans. Amer. Soc. Neurochem., 2, 78 (1971).

    Google Scholar 

  20. 20

    Wofsey, A. R., Kuhar, M. J., and Snyder, S. H., Proc. US Nat. Acad. Sci. (in the press).

  21. 21

    Curtis, D. R., Hösli, L., and Johnson, G. A. R., Exp. Brain Res., 6, 1 (1968).

    ADS  CAS  Article  Google Scholar 

  22. 22

    Neal, M. J., and Pickles, H. G., Nature, 222, 679 (1969).

    ADS  CAS  Article  Google Scholar 

  23. 23

    Johnston, G. A. R., and Iversen, L. L., J. Neurochem. (in the press).

Download references

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LOGAN, W., SNYDER, S. Unique High Affinity Uptake Systems for Glycine, Glutamic and Aspartic Acids in Central Nervous Tissue of the Rat. Nature 234, 297–299 (1971). https://doi.org/10.1038/234297b0

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