The excitement aroused by the idea that transformation of cells by RNA tumour viruses might depend on the activity of a reverse transcriptase enzyme(s) specific to the virus has stimulated much research since the enzyme was discovered in 1970. But the questions of the physical identity and catalytic activities of the enzyme(s), its function in transformation and whether it is unique to RNA tumour viruses remain unanswered.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Temin, H. M., Virology, 23, 486 (1964).
Temin, H. M., Cancer Res., 28, 1835 (1968).
Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).
Baltimore, D., Nature, 226, 1209 (1970).
Temin, H. M., J. Nat. Cancer Inst. (editorial), 46, III (1971).
Temin, H. M., Persp. Biol. Med., 14, 11 (1970).
Gallo, R. C., Blood (editorial) (in the press).
Culliton, B. J., Science, 172, 9 (1971).
Solomon, J., The Sciences, 2, 6 (1971).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 228, 430 (1970).
Schlom, J., Harter, D. H., Burny, A., and Spiegelman, S., Proc. US Nat. Acad. Sci., 68, 182 (1971).
Temin, H. M., Virology, 23, 486 (1964).
Bader, J. P., Virology, 22, 462 (1964).
Baluda, M. B., and Nayak, D. P., J. Virol., 4, 554 (1969).
Temin, H. M., Cancer. Res., 28, 1835 (1968).
Duesberg, P. H., Vogt, P. K., and Canaani, E., in Second Lepetit Colloquium on Biology and Medicine, The Biology of Oncogenic Viruses (edit. by Silvestri, L.) (North-Holland, Amsterdam, 1971).
Hanafusa, H., and Hanafusa, T., Virology, 43, 313 (1971).
Robinson, W. S., and Robinson, H. L., Virology, 44, 457 (1971).
Gurgo, D., Ray, R. K., Thiry, L., and Green, M., Nature, 229, 111 (1971).
Gallo, R. C., Yang, S. S., and Ting, R. C., Nature, 228, 927 (1970).
Gallo, R. C., Yang, S. S., Smith, R. G., Herrera, F., Ting, R. C., Bobrow, S. N., Davis, C., and Fujioka, S., in Second Lepetit Colloquium on Biology and Medicine, The Biology of Oncogenic Viruses (edit. by Silvestri, L.) (North-Holland, Amsterdam, 1971).
Yang, S. S., Smith, R. G., Ting, R. C., and Gallo, R. C., J. Nat. Cancer Inst. (in the press).
Brockman, W. W., Carter, W., Li, L. H., Reusser, F., and Nichol, F. R., Nature, 230, 249 (1971).
Carter, W. A., Brockman, W. W., and Borden, E. C., Nature New Biology, 232, 212 (1971).
Parkman, R., Levy, J. A., and Ting, R. C., Science, 168, 387 (1970).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).
Duesberg, P. H., and Canaani, E., Virology, 42, 783 (1970).
Mizutani, S., Boettiger, D., and Temin, H. M., Nature, 228, 424 (1970).
Kacian, D. L., Watson, K. F., Burny, A., and Spiegelman, S., Biochim. Biophys. Acta, 246, 365 (1971).
Duesberg, P., Helm, K. V. D., and Canaani, E., Proc. US Nat. Acad. Sci., 68, 747 (1971).
Ross, J., Scolnick, E. M., Todaro, G. J., and Aaronson, S. A., Nature New Biology, 231, 163 (1971).
Duesberg, P., Helm, K. V. D., and Canaani, E., Proc. US Nat. Acad. Sci., 68, 2505 (1971).
Baltimore, D., and Smoler, D., Proc. US Nat. Acad. Sci., 68, 1507 (1971).
Verma, I. M., Meuth, N. L., Bromfeld, E., Manly, K. F., and Baltimore, D., Nature New Biology, 233, 131 (1971).
Schlom, J., Spiegelman, S., and Moore, D., Nature, 231, 97 (1971).
Priori, E. S., Dmochowski, L., Myers, B., and Wilbur, J. R., Nature New Biology, 232, 61 (1971).
Gallo, R., Sarin, P., Allen, P., Newton, B., Bowen, J., Priori, E. S., and Dmochowski, L., Nature New Biology, 232, 140 (1971).
Wade, N., Science, 173, 1220 (1971).
Gerwin, B. I., Todaro, G., Zeve, V., Scolnick, E. M., and Aaronson, S. A., Nature, 228, 435 (1971).
Fujinaga, K., Parsons, J. T., Beard, J. W., Beard, D., and Green, M., Proc. US Nat. Acad. Sci., 67, 1432 (1970).
Spiegelman, S., Presented at the Second Colloquium on Biology and Medicine, Paris (1970).
Goodman, N. C., and Spiegelman, S., Proc. US Nat. Acad. Sci., 68, 2203 (1971).
Scolnick, E. M., Aaronson, S. A., Todaro, G. J., and Parks, W. P., Nature, 229, 318 (1971).
Aaronson, S., Parks, W. P., Scolnick, E. M., and Todaro, G. J., Proc. US Nat. Acad. Sci., 68, 920 (1971).
Scolnick, E. M., Presented at the Second International Congress of Virology, Budapest (1971).
Todaro, G., in US National Academy of Science Symposium (in the press).
Gallo, R. C., Yang, S. S., Smith, R. G., Herrera, F., Ting, R. C., and Fujioka, S., in Nucleic Acid-Protein Interactions and Nucleic Acid Synthesis in Viral Infection, Miami Winter Symposium (edit. by Ribbons, D. W., Woessner, J. F., and Schultz, J.) (North-Holland, Amsterdam, 1971).
Hirschman, S. Z., Science, 173, 441 (1971).
Müller, W. E. G., Zahn, R. K., and Seidal, H. J., Nature New Biology, 232, 143 (1971).
Tuominen, F. W., and Kenney, F. T., Proc. US Nat. Acad. Sci., 68, 2198 (1971).
Abrell, J., Smith, R. G., Robert, M., and Gallo, R. C. (unpublished results).
Yang, S. S., Ting, R. C., and Gallo, R. C., Proc. Amer. Assoc. Cancer Res., 12, 36 (1971).
Spiegelman, S., Presented at the Miami Winter Symposium on Nucleic Acid-Protein Interactions and Nucleic Acid Synthesis in Viral Infection (1971).
Lee-Huang, S., and Cavalieri, L. F., Proc. US Nat. Acad. Sci., 50, 1116 (1963).
Kiessling, A. A., Weber, G. H., Deeney, A. O., Possehl, E. A., and Beaudreau, G. S., J. Virol., 7, 221 (1971).
Penner, P. E., Cohen, L. H., and Loeb, L. A., Nature New Biology, 232, 58 (1971).
Müller, W. E. G., Yamazaki, Z., Zahn, R. K., Brehm, G., and Korting, G., Biochem. Biophys. Res. Commun., 44, 433 (1971).
Penner, P. E., Cohen, L. H., and Loeb, L. A., Biochem. Biophys. Res. Commun., 42, 1228 (1971).
Cavalieri, L. F., and Carroll, E., Biochem. Biophys. Res. Commun., 41, 1055 (1971).
Coffin, J., and Temin, H. M., J. Virol. (in the press).
Ackermann, W. W., Murphy, W. H., Miller, B. A., Kurtz, H., and Barker, S. T., Biochem. Biophys. Res. Commun., 42, 723 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GALLO, R. Molecular Biology: Reverse Transcriptase, the DNA Polymerase of Oncogenic RNA Viruses. Nature 234, 194–198 (1971). https://doi.org/10.1038/234194a0
Issue Date:
DOI: https://doi.org/10.1038/234194a0
This article is cited by
-
The Role of RNA-Sequencing as a New Genetic Diagnosis Tool
Current Genetic Medicine Reports (2021)
-
The chronology of AIDS research
Nature (1987)
-
RNase-sensitive DNA polymerase activity in cell fractions and mutants of Neurospora crassa
Biochemical Genetics (1980)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.