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Effect of Steroids and Dibutyryl Cyclic AMP on the Sensitivity of Haemopoietic Stem Cells to 3H-Thymidine in vitro

Nature volume 234, pages 39–40 (1971)Cite this article

Abstract

AN early action of testosterone and chemically related steroids is to increase the sensitivity of spleen colony forming units (CFU) to the cytocidal action of high specific activity 3H-thymidine1. This can be observed as early as 6 h after a single subcutaneous injection of steroid. CFU of normal adult miec are generally insensitive to the killing action of 3H-thymidine2; hence the effect of steroids was interpreted as either triggering CFU from a resting (Go) stage into cell cycle, or shortening the cell cycle of CFU.

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Authors and Affiliations

  1. Haematology-Pharmacology Laboratory, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX

    J. W. BYRON

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  1. J. W. BYRON
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BYRON, J. Effect of Steroids and Dibutyryl Cyclic AMP on the Sensitivity of Haemopoietic Stem Cells to 3H-Thymidine in vitro. Nature 234, 39–40 (1971). https://doi.org/10.1038/234039a0

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