Abstract
THE marked geographical distribution of Burkitt's lymphoma in Africa has suggested that the aetiological agent is infectious and arthropod-borne1,2. A herpes-like virus, first described by Epstein et al.3, has been associated consistently with lymphoid cells cultured from cases of Burkitt's lymphoma4. Furthermore, immunofluorescent tests, using Burkitt lymphoma cells, have demonstrated antibodies against this Epstein-Barr virus (EBV) in all sera from patients with Burkitt's lymphoma and in sera from many healthy African controls living in the endemic regions5–6. These observations indicate that EBV infection is widespread, and suggest that the virus in some individuals might be involved in the development of Burkitt's tumour.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Burkitt, D. Brit. J. Surg., 46, 218 (1958).
Burkitt, D., and Davies, J. N. P., Med. Press, 245, 367 (1961).
Epstein, M. A., Achong, B. G., and Barr, Y. M., Lancet, ii, 702 (1964).
Henle, G., and Henle, W., Trans. NY Acad. Sci., 29, 71 (1966).
Henle, G., and Henle, W., J. Bact., 91, 1248 (1966).
Levy, J. A., and Henle, G., J. Bact., 92, 275 (1966).
Burkitt, D. P., E. African Med. J., 38, 511 (1961).
Haddow, A. T., E. African Med. J., 40, 429 (1963).
Pike, M. C., Williams, E. H., and Wright, B., Brit. Med. J., 2, 395 (1967).
Williams, M. C., UICC Monog., 8, 42 (1967).
Dalldorf, G., Linsell, C. A., Bernhart, F. F., and Martyn, R., Perspect. Biol. Med., 7, 435 (1964).
Kafuko, G. W., and Burkitt, D. P., Intern. J. Cancer, 6, 1 (1970).
Goma, L. K. H., East African Virus Res. Inst. Rep., p. 34 (1962–63).
Banfield, W. G., Woke, P. A., MacKay, C. M., and Cooper, H. L., Science, 148, 1239 (1965).
Gerber, P., and Birch, S., Proc. US Nat. Acad. Sci., 58, 478 (1967).
Landon, J. C., Ellis, L. B., Zeve, V. H., and Fabrizio, D. P. A., J. Nat. Cancer Inst., 40, 181 (1968).
Gerber, P., and Rosenblum, E., Proc. Soc. Exp. Biol. Med., 128, 541 (1968).
Bree, M. M., Lab. Animal Care, 17, 547 (1967).
Chen, G., Glazko, A. J., and Kaunp, D. H., CI-581, Revised Lab. Summary (Exp. Therap. Dept. Res. Div., Parke, Davis and Co., Jan. 15, 1968).
Pulvertaft, R. J. V., Lancet, i, 238 (1964).
Hirshaut, Y., Glade, P., Vieira, L. O. B. D., Aurhender, E., Dvorak, B., and Siltzbach, L. E., New Engl. J. Med., 283, 502 (1970).
Goldman, M., Landon, J. C., and Reischer, J. I., Cancer Res., 28, 2489 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LEVY, J., LEVY, S., HIRSHAUT, Y. et al. Presence of EBV Antibodies in Sera from Wild Chimpanzees. Nature 233, 559–560 (1971). https://doi.org/10.1038/233559a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/233559a0
This article is cited by
-
Comparative analysis of genomes of oncogenic B-lymphotropic herpesviruses reproducing in cell lines obtained from different species of monkeys
Bulletin of Experimental Biology and Medicine (1990)
-
Antibodies to Simian C-type Virus Antigen in Sera of Gibbons (Hylobates sp.)
Nature New Biology (1973)
-
EBV Antibody in Sera of Non-human Primates
Nature (1972)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
