Abstract
THE marked geographical distribution of Burkitt's lymphoma in Africa has suggested that the aetiological agent is infectious and arthropod-borne1,2. A herpes-like virus, first described by Epstein et al.3, has been associated consistently with lymphoid cells cultured from cases of Burkitt's lymphoma4. Furthermore, immunofluorescent tests, using Burkitt lymphoma cells, have demonstrated antibodies against this Epstein-Barr virus (EBV) in all sera from patients with Burkitt's lymphoma and in sera from many healthy African controls living in the endemic regions5–6. These observations indicate that EBV infection is widespread, and suggest that the virus in some individuals might be involved in the development of Burkitt's tumour.
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References
- 1
Burkitt, D. Brit. J. Surg., 46, 218 (1958).
- 2
Burkitt, D., and Davies, J. N. P., Med. Press, 245, 367 (1961).
- 3
Epstein, M. A., Achong, B. G., and Barr, Y. M., Lancet, ii, 702 (1964).
- 4
Henle, G., and Henle, W., Trans. NY Acad. Sci., 29, 71 (1966).
- 5
Henle, G., and Henle, W., J. Bact., 91, 1248 (1966).
- 6
Levy, J. A., and Henle, G., J. Bact., 92, 275 (1966).
- 7
Burkitt, D. P., E. African Med. J., 38, 511 (1961).
- 8
Haddow, A. T., E. African Med. J., 40, 429 (1963).
- 9
Pike, M. C., Williams, E. H., and Wright, B., Brit. Med. J., 2, 395 (1967).
- 10
Williams, M. C., UICC Monog., 8, 42 (1967).
- 11
Dalldorf, G., Linsell, C. A., Bernhart, F. F., and Martyn, R., Perspect. Biol. Med., 7, 435 (1964).
- 12
Kafuko, G. W., and Burkitt, D. P., Intern. J. Cancer, 6, 1 (1970).
- 13
Goma, L. K. H., East African Virus Res. Inst. Rep., p. 34 (1962–63).
- 14
Banfield, W. G., Woke, P. A., MacKay, C. M., and Cooper, H. L., Science, 148, 1239 (1965).
- 15
Gerber, P., and Birch, S., Proc. US Nat. Acad. Sci., 58, 478 (1967).
- 16
Landon, J. C., Ellis, L. B., Zeve, V. H., and Fabrizio, D. P. A., J. Nat. Cancer Inst., 40, 181 (1968).
- 17
Gerber, P., and Rosenblum, E., Proc. Soc. Exp. Biol. Med., 128, 541 (1968).
- 18
Bree, M. M., Lab. Animal Care, 17, 547 (1967).
- 19
Chen, G., Glazko, A. J., and Kaunp, D. H., CI-581, Revised Lab. Summary (Exp. Therap. Dept. Res. Div., Parke, Davis and Co., Jan. 15, 1968).
- 20
Pulvertaft, R. J. V., Lancet, i, 238 (1964).
- 21
Hirshaut, Y., Glade, P., Vieira, L. O. B. D., Aurhender, E., Dvorak, B., and Siltzbach, L. E., New Engl. J. Med., 283, 502 (1970).
- 22
Goldman, M., Landon, J. C., and Reischer, J. I., Cancer Res., 28, 2489 (1968).
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LEVY, J., LEVY, S., HIRSHAUT, Y. et al. Presence of EBV Antibodies in Sera from Wild Chimpanzees. Nature 233, 559–560 (1971). https://doi.org/10.1038/233559a0
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