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Effects of 6-Hydroxydopamine on Sleep in the Rat

Abstract

THERE is evidence that biogenic amines are involved in the mechanisms of sleep1,2. Although the exact relationship is not clear, recent results suggest that decreases in the concen-tration of catecholamines (noradrenaline or dopamine) in the brain cause increased desynchronized sleep (D) (sleep with rapid desynchronized cortical activity, also known as paradoxical or REM sleep), whereas increases in the concentration of catecholamines decrease D3–5. Not all the results, however, are in agreement1,2,6.

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HARTMANN, E., CHUNG, R., DRASKOCZY, P. et al. Effects of 6-Hydroxydopamine on Sleep in the Rat. Nature 233, 425–427 (1971). https://doi.org/10.1038/233425a0

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