Abstract
Particles apparently similar to type B mouse mammary tumour virus, which are found in human milk and may be associated with breast cancer, contain reverse transcriptase activity. Milks lacking the particles do not have this activity. This finding will help to establish the relationship between these particles and tumour viruses.
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References
Moore, D. H., Sarkar, N. H., Kelly, C. E., Pillsbury, N., and Charney, J., Texas Rep. Biol. Med., 27, 1027 (1969).
Moore, D. H., Charney, J., Kramarsky, B., Lasfargues, E. Y., Sarkar, N. H., Brennan, M. J., Burrows, J. H., Sirsat, S. M., Paymaster, J. C., and Vaidya, A. B., Nature, 229, 611 (1971).
Feller, W. F., Chopra, H. C., and Bepko, F., Surgery, 62, 750 (1967).
Dmochowski, L., Seman, G., Myers, B., and Gallager, H. S., Med. Rec. Ann., 61, 384 (1968).
Feller, W. F., and Chopra, H. C., Cancer, 24, 1250 (1969).
Chopra, H. C., and Feller, W. F., Texas Rep. Biol. Med., 27, 945 (1969).
Jussawalla, D. J., Deshpande, V. A., Haenszel, W., and Natekar, M. V., Brit. J. Cancer, 24, 56 (1970).
Paymaster, J. C., and Gangardharan, P., Intern. J. Cancer, 5, 426 (1970).
Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).
Baltimore, D., Nature, 226, 1209 (1970).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 228, 430 (1970).
Lee-Huang, S., and Cavalleri, L. F., Proc. US Nat. Acad. Sci., 51, 1022 (1964).
Scolnick, E. M., Aaronson, S. A., Todaro, G. J., and Parks, W. P., Nature, 229, 318 (1971).
Moore, D. H., Pillsbury, N., and Pullinger, B. D., J. Nat. Cancer Inst., 43, 1263 (1969).
Chopra, H. C., and Mason, M. M., Cancer Res., 30, 2081 (1970).
Schlom, J., Harter, D. H., Burny, A., and Spiegelman, S., Proc. US Nat. Acad. Sci., 68, 182 (1971).
Takamoto, K., and Stone, L. B., J. Virol. (in the press).
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SCHLOM, J., SPIEGELMAN, S. & MOORE, D. RNA-dependent DNA Polymerase Activity in Virus-like Particles isolated from Human Milk. Nature 231, 97–100 (1971). https://doi.org/10.1038/231097a0
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DOI: https://doi.org/10.1038/231097a0
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