Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Calcium Shift into Bone causing Transient Hypocalcaemia after Injection of Parathyroid Hormone

Nature volume 230, pages 581–582 (1971)Cite this article

Abstract

AFTER intravenous injection of parathyroid hormone (PTH) in man and several animals, the plasma calcium concentration decreases transiently before rising, and this effect is usually attributed to calcitonin contamination of the parathyroid hormone. We now report an investigation in the rat with calcitonin-free hormone which shows that the transient hypocalcaemia is due to PTH itself and results from a rapid flow of calcium into the skeleton. These results supply evidence to strengthen current suggestions that entry of calcium into bone cells occurs very early in the response of PTH and may represent its primary action.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Parsons, J. A., and Robinson, C. J., in Parathyroid Hormone and Thyrocalcitonin (edit. by Talmage, R. V., and Bélanger, L. F.), 329 (Excerpta Medica, Amsterdam, 1968).

    Google Scholar 

  2. Parsons, J. A., Neer, R. M., and Potts, J. T., Endocrinology, 88 (in the press).

  3. Munson, P. L., in The Parathyroids (edit. by Greep, R. O., and Talmage, R. V.), 94 (Thomas, Illinois, 1961).

    Google Scholar 

  4. Parsons, J. A., Dawson, B., Callahan, E., and Potts, J. T., Biochem. J., 119, 791 (1970).

    Article  CAS  Google Scholar 

  5. MacIntyre, I., Adv. Clin. Chem., 4, 1 (1961).

    Article  CAS  Google Scholar 

  6. Donaldson, H. H., in The Rat (Wistar Institute, Philadelphia, 1924).

    Google Scholar 

  7. Huang, K. C., and Bondurant, J. H., Amer. J. Physiol., 185, 441 (1956).

    CAS  PubMed  Google Scholar 

  8. Tashjian, A. H., Ontjes, D. A., and Munson, P. L., Biochemistry, 3, 1175 (1964).

    Article  Google Scholar 

  9. Neuman, W. F., in The Parathyroid Glands (edit. by Gaillard, P. J., Talmage, R. V., and Budy, A. M.), 175 (University of Chicago Press, 1965).

    Google Scholar 

  10. Copp, D. H., and Cameron, E. C., Science, 134, 2038 (1961).

    Article  ADS  CAS  Google Scholar 

  11. Copp, D. H., Davidson, A. G. F., and Cheney, B. A., Proc. Canad. Fed. Biol. Soc., 4, 17 (1961).

    Google Scholar 

  12. Copp, D. H., Cameron, E. C., Cheney, B. A., Davidson, A. G. F., and Henze, K. G., Endocrinology, 70, 638 (1962).

    Article  CAS  Google Scholar 

  13. Haas, H. G., Affolter, H., and Dubach, V. C., Acta Endocrinol., 48, 132 (1965).

    Article  CAS  Google Scholar 

  14. Copp, D. H., in The Parathyroid Glands (edit. by Gaillard, P. J., Talmage, R. V., and Budy, A. M.), 73 (University of Chicago Press, 1965).

    Google Scholar 

  15. Care, A. D., Keynes, W. M., and Duncan, T., J. Endocrinol., 34, 299 (1966).

    Article  CAS  Google Scholar 

  16. Tiselius, P., Engfeldt, B., Porath, J., Wallenius, G., and Werner, I., Metabolism, 13, 929 (1964).

    Article  CAS  Google Scholar 

  17. Mulryan, B. J., Neuman, M. W., Neuman, W. F., and Toribara, T. Y., Amer. J. Physiol., 207, 947 (1964).

    CAS  PubMed  Google Scholar 

  18. Borle, A. B., J. Cell. Biol., 36, 567 (1968).

    Article  CAS  Google Scholar 

  19. Borle, A. B., in Parathyroid Hormone and Thyrocalcitonin (edit. by Talmage, R. V., and Bélanger, L. F.), 258 (Excerpta Medica, Amsterdam, 1968).

    Google Scholar 

  20. Charbon, G. A., Europ. J. Pharmacol., 3, 275 (1968).

    Article  CAS  Google Scholar 

  21. Weinman, D. T., Kelly, P. J., Owen, C. A., and Orvis, A. L., Proc. Staff Mtg Mayo Clin., 38, 559 (1963).

    CAS  Google Scholar 

  22. Copp, D. H., and Shim, S. S., Circulation Res., 16, 461 (1965).

    Article  CAS  Google Scholar 

  23. Talmage, R. V., Clin. Orthop., 67, 210 (1969).

    Article  Google Scholar 

  24. Talmage, R. V., Cooper, C. W., and Park, H. Z., Vitamins and Hormones, 28 (1970).

  25. Rasmussen, H., and Tenenhouse, A., in Biochemical Actions of Hormones (edit. by Litwack, G.), 365 (Academic Press, New York, 1970).

    Book  Google Scholar 

  26. Chase, L. R., and Aurbach, G. D., in Parathyroid Hormone and Thyrocalcitonin (edit. by Talmage, R. V., and Bélanger, L. F.), 247 (Excerpta Medica, Amsterdam, 1968).

    Google Scholar 

  27. Chase, L. R., Fedak, S. A., and Aurbach, G. D., Endocrinology, 84, 761 (1969).

    Article  CAS  Google Scholar 

  28. Rasmussen, H., Science, 170, 404 (1970).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, NW7

    J. A. PARSONS & C. J. ROBINSON

Authors
  1. J. A. PARSONS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. J. ROBINSON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PARSONS, J., ROBINSON, C. Calcium Shift into Bone causing Transient Hypocalcaemia after Injection of Parathyroid Hormone. Nature 230, 581–582 (1971). https://doi.org/10.1038/230581a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/230581a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing