Abstract
LEE and his co-workers have reported1–3, and we have confirmed, that α-bungarotoxin (α-BuTX), a component of the venom of a Formosan snake (Bungarus multicinctus), blocks specifically and irreversibly the depolarizing action of acetylcholine at vertebrate neuromuscular junctions. We wish to report that this toxin similarly blocks the cholinergically innervated electric tissue of Torpedo marmorata, and to describe isolation of the single membrane protein to which the toxin is bound.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Chang, C. C., and Lee, C. Y., Arch. Intern. Pharmacodyn., 144, 241 (1963).
Lee, C. Y., and Chang, C. C., Mem. Inst. Butantan. Simp. Internac., 33, 555 (1966).
Lee, C. Y., and Tseng, L. F., Toxicon, 3, 281 (1966).
Pacini, F., Gazz. Med. Ital. Fed. Tosc., second series, 2 (1852).
Nickel, E., and Potter, L. T., Brain Res., 23, 95 (1970).
Feldberg, W., and Fessard, A., J. Physiol., 101, 200 (1942).
Israël, M., Arch. D' Anat. Microscop., 59, 5 (1970).
Pressman, D., and Eisen, H. N., J. Immunol., 64, 273 (1950).
Gotch, F., J. Physiol., 9, 6P (1888).
Schönlein, K., Z. Biol., 33, 408 (1896).
Auger, D., and Fessard, A., CR Soc. Biol., 135, 76 (1941).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Ellman, G. L., Courtney, K. D., Andres, V., and Featherstone, R. M., Biochem. Pharmacol., 7, 88 (1961).
Kremzner, L. T., and Wilson, I. B., Biochemistry, 3, 1902 (1964).
Changeux, J.-P., Kasai, M., and Lee, C. H., Proc. US Nat. Acad. Sci., 67, 1241 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MILEDI, R., MOLINOFF, P. & POTTER, L. Biological Sciences: Isolation of the Cholinergic Receptor Protein of Torpedo Electric Tissue. Nature 229, 554–557 (1971). https://doi.org/10.1038/229554a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/229554a0
This article is cited by
-
Targeting Brain α7 Nicotinic Acetylcholine Receptors in Alzheimer’s Disease: Rationale and Current Status
CNS Drugs (2014)
-
Historical evolution of the neurotransmission concept
Journal of Neural Transmission (2009)
-
Actions of snake neurotoxins on an insect nicotinic cholinergic synapse
Invertebrate Neuroscience (2007)
-
The receptor concept: pharmacology's big idea
British Journal of Pharmacology (2006)
-
Emerging structure of the Nicotinic Acetylcholine receptors
Nature Reviews Neuroscience (2002)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
