Abstract
THE longitudinal growth of bones is the result of cell proliferation within a comparatively simple linear system. When once the form of the epiphyseal growth plate has been established at about the time of weaning, the dividing cells arrange themselves in an orderly columnar pattern orientated in the direction of growth. Within each column there is a resting cell zone; a proliferation zone; a maturation zone where cells increase in size; and a hypertrophic zone in which the intercellular matrix becomes calcified before the cells are eventually invaded by metaphyseal capillary tufts.
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KEMBER, N., WALKER, K. Control of Bone Growth in Rats. Nature 229, 428–429 (1971). https://doi.org/10.1038/229428a0
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DOI: https://doi.org/10.1038/229428a0
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